Results 51 to 60 of about 507,870 (221)

Cell cycle regulation of deoxycytidine kinase Evidence for post-transcriptional control [PDF]

, 1993
Deoxycytidine kinase enzyme activity and deoxycitidine kinase mRNA content were determined at different positions of the cell cycle in permanent cell lines.
Hengstschläger, Markus, Markus Hengstschläger, Denk, Claudia, Wawra, Edgar, Edgar Wawra, Claudia Denk   +5 more
core   +1 more source

SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro

BMC Cancer, 2008
Background Suppressor of cytokine signaling 3 (SOCS3) is considered to inhibit cytokine responses and play a negative role in migration of various cells.
Zhang Qingfu, Jiang Lili, Guo Dawei, Zhang Siyang, Qiu Xueshan, Wang Enhua   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Bioavailability and cytosolic kinases modulate response to deoxynucleoside therapy in TK2 deficiencyResearch in context

EBioMedicine, 2019
Background: TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage pathway.
Carlos Lopez-Gomez, Henly Hewan, Carlos Sierra, Hasan O. Akman, Maria J. Sanchez-Quintero, Marti Juanola-Falgarona, Saba Tadesse, Kurenai Tanji, Elisa E. Konofagou, Michio Hirano   +9 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency

EMBO Molecular Medicine, 2014
Autosomal recessive mutations in the thymidine kinase 2 gene (TK2) cause mitochondrial DNA depletion, multiple deletions, or both due to loss of TK2 enzyme activity and ensuing unbalanced deoxynucleotide triphosphate (dNTP) pools.
Caterina Garone, Beatriz Garcia‐Diaz, Valentina Emmanuele, Luis C Lopez, Saba Tadesse, Hasan O Akman, Kurenai Tanji, Catarina M Quinzii, Michio Hirano   +8 more
doaj   +1 more source

Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma

Scientific Reports, 2021
Adenylate kinase 5 (AK5) belongs to the adenylate kinase family that catalyses reversible phosphate transfer between adenine nucleotides, and it is related to various energetic signalling mechanisms.
Bokyung Ahn, Yang Seok Chae, Soo Kyung Lee, Moa Kim, Hyeon Soo Kim, Ji Wook Moon, Sun-Hwa Park   +6 more
doaj   +1 more source

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Enhancing the Nucleoside Analog Response with Translational Therapeutic Approaches to Overcome Resistance

Cells
Nucleoside analogs remain central to the treatment of hematologic malignancies and solid tumors, yet resistance frequently occurs, contributing to relapse and disease-related mortality.
Jenna Thibodeau, Kian Hershberger, Sai Samanvitha M. Ramakrishna, Yongwei Su, Lauren Timmer, Bryce Brophy, Katherine Zhang, Holly Edwards, Jeffrey W. Taub, Yubin Ge   +9 more
doaj   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source