Results 31 to 40 of about 507,870 (221)

Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models

Experimental Hematology & Oncology, 2020
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor response to chemo- and (modest-dose conventionally fractionated) radio-therapy. Emerging evidence suggests that pancreatic stellate cells (PSCs) secrete deoxycytidine, which confers resistance
Pei Pei Che, Alessandro Gregori, Omidreza Firuzi, Max Dahele, Peter Sminia, Godefridus J. Peters, Elisa Giovannetti   +6 more
doaj   +1 more source

The Intracellular Localization of Deoxycytidine Kinase [PDF]

Journal of Biological Chemistry, 1998
Deoxycytidine kinase (dCK) catalyzes the rate-limiting step of the deoxynucleoside salvage pathway in mammalian cells and plays a key role in the activation of several pharmacologically important nucleoside analogs. Using a highly specific polyclonal antibody raised against a C-terminal peptide of the human dCK, we analyzed its subcellular localization
P, Hatzis, A S, Al-Madhoon, M, Jüllig, T G, Petrakis, S, Eriksson, I, Talianidis   +5 more
openaire   +2 more sources

DCK is an Unfavorable Prognostic Biomarker and Correlated With Immune Infiltrates in Liver Cancer

Technology in Cancer Research & Treatment, 2020
Background: The biological function of deoxycytidine kinase in tumor is not yet clear, and there are a few studies relating to the correlation of deoxycytidine kinase gene with the occurrence and development of liver cancer.
Shu Fang Hu MM, Xia Lin PhD, Lv Ping Xu MBBS, Hong Gang Chen MBBS, Ju Feng Guo MM, Li Jin MM   +5 more
doaj   +1 more source

TMSOTf assisted synthesis of 2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine ([18F]FAC). [PDF]

PLoS ONE, 2018
[18F]FAC (2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine, 1) is a versatile probe for imaging deoxycytidine kinase (dCK) expression levels in vivo.
Kishore K Gangangari, John L Humm, Steven M Larson, Naga Vara Kishore Pillarsetty   +3 more
doaj   +1 more source

A Humanized Yeast Phenomic Model of Deoxycytidine Kinase to Predict Genetic Buffering of Nucleoside Analog Cytotoxicity. [PDF]

Genes (Basel), 2019
Knowledge about synthetic lethality can be applied to enhance the efficacy of anticancer therapies in individual patients harboring genetic alterations in their cancer that specifically render it vulnerable.
Santos SM, Icyuz M, Pound I, William D, Guo J, McKinney BA, Niederweis M, Rodgers J, Hartman JL.   +8 more
europepmc   +2 more sources

Human equilibrative nucleoside transporter 1 (hENT1) and deoxycytidine kinase (DCK) are predictive biomarkers for Gemcitabine-based chemoradiotherapy in resected pancreatic cancer patients: a retrospective cohort study

Al-Azhar Assiut Medical Journal, 2023
Background and Aim Pancreatic cancer is reported to be one of the cancer-related deaths all over the world. Gemcitabine has been identified as one of the important therapies of malignant diseases.
Abdelhalim A Elsherif, Yuzo Kodama, Norimitsu Uza, Mohammed S Hussein, Mostafa Elhawary   +4 more
doaj   +1 more source

Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the molecules [PDF]

Acta Crystallographica Section D: Biological Crystallography, 2014
Arnon Lavie, Steven Olson, Jennifer Murphy   +2 more
exaly   +2 more sources

DCK is a promising prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

World Journal of Surgical Oncology, 2020
Background Deoxycytidine kinase (DCK), an enzyme in the nucleoside biosynthetic pathway, can affect the development of immune cells. However, the relationships between the expression of DCK, patient prognosis, and tumor-infiltrating immune cells (TIICs ...
Danjun Song, Yining Wang, Kai Zhu, Lingyu Tian, Qiang Gao, Jian Zhou, Jia Fan, Xiaoying Wang   +7 more
doaj   +1 more source

Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology

Nature Communications, 2017
Masitinib is a protein kinase inhibitor that sensitises refractory pancreatic adenocarcinoma cells to treatment with the nucleoside analog gemcitabine.
Kahina Hammam, Magali Saez-Ayala, Etienne Rebuffet, Laurent Gros, Sophie Lopez, Berengere Hajem, Martine Humbert, Emilie Baudelet, Stephane Audebert, Stephane Betzi, Adrien Lugari, Sebastien Combes, Sebastien Letard, Nathalie Casteran, Colin Mansfield, Alain Moussy, Paulo De Sepulveda, Xavier Morelli, Patrice Dubreuil   +18 more
doaj   +1 more source

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity

The Journal of Clinical Investigation, 2022
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is ...
Evan R. Abt, Khalid Rashid, Thuc M. Le, Suwen Li, Hailey R. Lee, Vincent Lok, Luyi Li, Amanda L. Creech, Amanda N. Labora, Hanna K. Mandl, Alex K. Lam, Arthur Cho, Valerie Rezek, Nanping Wu, Gabriel Abril-Rodriguez, Ethan W. Rosser, Steven D. Mittelman, Willy Hugo, Thomas Mehrling, Shanta Bantia, Antoni Ribas, Timothy R. Donahue, Gay M. Crooks, Ting-Ting Wu, Caius G. Radu   +24 more
doaj   +1 more source