Results 31 to 40 of about 14,531 (182)
A general method for purification of deoxycytidine kinase [PDF]
Biochemical Journal, 1978 Deoxycytidine kinase from a variety of animal tissues binds to Cibacron Blue 3G-A coupled to Sepharose CL-6B. The enzyme can be selectively eluted with ATP to yield single-step purifications of 17-89-fold. The affinity adsorbent is re-usable.
A, Baxter, L M, Currie, J P, Durham
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PRKCDBP Methylation is a Potential and Promising Candidate Biomarker for Non-small Cell Lung Cancer
Chinese Journal of Lung Cancer, 2022 Background and objectives: The occurrence and development of lung cancer are closely linked to epigenetic modification. Abnormal DNA methylation in the CpG island region of genes has been found in many cancers.
Jing LI +8 more
doaj +1 more source
Preventive electroacupuncture reduces cognitive deficits in a rat model of D-galactose-induced aging
Neural Regeneration Research, 2021 Acupuncture can reduce cognitive deficits in Alzheimer’s disease. However, whether electroacupuncture can prevent or alleviate the cognitive deficits in animal models of aging remains poorly understood.
Chao-Chao Yu +10 more
doaj +1 more source
Angewandte Chemie, EarlyView.State‐of‐the‐art synthesis of radiolabelled oligonucleotides involves multi‐step synthesis with high costs, extended timelines and significant radioactive waste generation. Herein, a dual‐methyltransferase platform enables late‐stage, site‐specific labelling, overcoming these limitations through reduced costs, faster turnaround and minimal radioactive ...
Christopher R. B. Swanson +3 more
wiley +2 more sources
mSphere, 2019 Cytidine deaminase (CDA) is a pyrimidine salvage enzyme that catalyzes cytidine and deoxycytidine hydrolytic deamination to yield uridine and deoxyuridine.
Ana Moro-Bulnes +6 more
doaj +1 more source
International Journal of Preventive Medicine, 2021 Background: The cell cycle is divided into four phases, G1, G2, S, and M phase. The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin and the cyclin-dependent kinase (CDK), cyclin-CDK complexes.
Masumeh Sanaei +2 more
doaj +1 more source
Preclinical development of non-viral gene therapy for patients with advanced pancreatic cancer
Molecular Therapy: Methods & Clinical Development, 2023 Pancreatic cancer remains one of the greatest challenges in oncology for which therapeutic intervention is urgently needed. We previously demonstrated that the intra-tumoral gene transfer of somatostatin receptor 2, to combat tumor aggressiveness, or of ...
Odile Barbey +9 more
doaj +1 more source
Human deoxycytidine kinase is located in the cell nucleus [PDF]
Proceedings of the National Academy of Sciences, 1997 Human deoxyribonucleoside kinases are required for the pharmacological activity of several clinically important anticancer and antiviral nucleoside analogs. Human deoxycytidine kinase and thymidine kinase 1 are described as cytosolic enzymes in the literature, whereas human deoxyguanosine kinase and thymidine kinase 2 are believed ...
M, Johansson, S, Brismar, A, Karlsson
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SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro
BMC Cancer, 2008 Background Suppressor of cytokine signaling 3 (SOCS3) is considered to inhibit cytokine responses and play a negative role in migration of various cells.
Zhang Qingfu +5 more
doaj +1 more source
EBioMedicine, 2019 Background: TK2 is a nuclear gene encoding the mitochondrial matrix protein thymidine kinase 2 (TK2), a critical enzyme in the mitochondrial nucleotide salvage pathway.
Carlos Lopez-Gomez +9 more
doaj +1 more source