Results 21 to 30 of about 34,947 (246)

Molecular Imaging of Deoxycytidine Kinase Activity Using Deoxycytidine-Enhanced CEST MRI [PDF]

Cancer Research, 2019
Abstract Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance.
Zheng, Han, Yuguo, Li, Jia, Zhang, Jing, Liu, Chuheng, Chen, Peter C, van Zijl, Guanshu, Liu   +6 more
openaire   +2 more sources

Effects of DACT1 methylation status on invasion and metastasis of nasopharyngeal carcinoma

Biological Research, 2019
Background The purpose of the present study was to investigate the role of the methylation status of the DACT1 gene on the invasion and metastasis of nasopharyngeal carcinoma cells.
Ju-Hong Yang, Lie-Kun Lin, Song Zhang
doaj   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. [PDF]

PLoS ONE, 2014
Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. We show that ataxia telangiectasia mutated (ATM) integrates the DNA damage response with DNA metabolism by regulating the salvage of deoxyribonucleosides ...
Yuri L Bunimovich, Evan Nair-Gill, Mireille Riedinger, Melissa N McCracken, Donghui Cheng, Jami McLaughlin, Caius G Radu, Owen N Witte   +7 more
doaj   +1 more source

Identification of novel DNA methylation inhibitors via a two-component reporter gene system

Journal of Biomedical Science, 2011
Background Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors azacytidine and 5-aza-2 ...
Chen Ching-Shih, Huang Tim HM, Tseng Min-Jen, Teng I-Wen, Hsu Chia-Chen, Wang Shi-Gang, Shaw Arthur Y, Lin Yi-Shiuan, Leu Yu-Wei, Hsiao Shu-Huei   +9 more
doaj   +1 more source

Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity

The Journal of Clinical Investigation, 2022
Purine nucleoside phosphorylase (PNP) enables the breakdown and recycling of guanine nucleosides. PNP insufficiency in humans is paradoxically associated with both immunodeficiency and autoimmunity, but the mechanistic basis for these outcomes is ...
Evan R. Abt, Khalid Rashid, Thuc M. Le, Suwen Li, Hailey R. Lee, Vincent Lok, Luyi Li, Amanda L. Creech, Amanda N. Labora, Hanna K. Mandl, Alex K. Lam, Arthur Cho, Valerie Rezek, Nanping Wu, Gabriel Abril-Rodriguez, Ethan W. Rosser, Steven D. Mittelman, Willy Hugo, Thomas Mehrling, Shanta Bantia, Antoni Ribas, Timothy R. Donahue, Gay M. Crooks, Ting-Ting Wu, Caius G. Radu   +24 more
doaj   +1 more source

Identification of Novel HLA-A*24:02-Restricted Epitope Derived from a Homeobox Protein Expressed in Hematological Malignancies. [PDF]

PLoS ONE, 2016
The homeobox protein, PEPP2 (RHOXF2), has been suggested as a cancer/testis (CT) antigen based on its expression pattern. However, the peptide epitope of PEPP2 that is recognized by cytotoxic T cells (CTLs) is unknown.
Maiko Matsushita, Yohei Otsuka, Naoya Tsutsumida, Chiaki Tanaka, Akane Uchiumi, Koji Ozawa, Takuma Suzuki, Daiju Ichikawa, Hiroyuki Aburatani, Shinichiro Okamoto, Yutaka Kawakami, Yutaka Hattori   +11 more
doaj   +1 more source

Study of the multiple incorporation of modified nucleotides into the growing DNA strand

Тонкие химические технологии, 2021
Objectives. This study investigated the substrate properties of the modified derivatives of triphosphates of purine and pyrimidine deoxynucleosides (5-propynyl-2’-deoxyuridine-5’-triphosphate, 5-propynyl2’-deoxycytidine-5’-triphosphate, 5-methyl-2 ...
O. S. Volkova, A. V. Chudinov, S. A. Lapa   +2 more
doaj   +1 more source

Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma

Clinical Epigenetics, 2019
Background Efficient treatments against metastatic melanoma dissemination are still lacking. Here, we report that low-cytotoxic concentrations of 5-aza-2′-deoxycytidine, a DNA demethylating agent, prevent in vitro 3D invasiveness of metastatic melanoma ...
Cécile Desjobert, Arnaud Carrier, Audrey Delmas, Diego M. Marzese, Antoine Daunay, Florence Busato, Arnaud Pillon, Jörg Tost, Joëlle Riond, Gilles Favre, Chantal Etievant, Paola B. Arimondo   +11 more
doaj   +1 more source

Kaiso interacts with p120-catenin to regulate β-catenin expression at the transcriptional level. [PDF]

PLoS ONE, 2014
BACKGROUND: We have reported that p120-catenin could regulate β-catenin transcription in lung cancer cells, but the specific mechanism is unclear. METHODS AND RESULTS: In this study, bisulfite sequencing PCR showed that the β-catenin promoter region in ...
Yang Liu, Qian-Ze Dong, Si Wang, Hong-Tao Xu, Yuan Miao, Liang Wang, En-Hua Wang   +6 more
doaj   +1 more source