PLoS ONE, 2015 BackgroundReplication-independent active/enzymatic demethylation may be an important process in the functioning of somatic cells. The most plausible mechanisms of active 5-methylcytosine demethylation, leading to activation of previously silenced genes ...
Daniel Gackowski +4 more
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TMSOTf assisted synthesis of 2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine ([18F]FAC). [PDF]
PLoS ONE, 2018 [18F]FAC (2'-deoxy-2'-[18F]fluoro-β-D-arabinofuranosylcytosine, 1) is a versatile probe for imaging deoxycytidine kinase (dCK) expression levels in vivo.
Kishore K Gangangari +3 more
doaj +1 more source
Detection of oxidation products of 5-methyl-2'-deoxycytidine in Arabidopsis DNA. [PDF]
PLoS ONE, 2013 Epigenetic regulations play important roles in plant development and adaptation to environmental stress. Recent studies from mammalian systems have demonstrated the involvement of ten-eleven translocation (Tet) family of dioxygenases in the generation of
Shuo Liu +5 more
doaj +1 more source
Research progress of dCTP pyrophosphatase 1 regulating nucleotide metabolism and phenotype of tumor cells [PDF]
Jichu yixue yu linchuang, 2021 Deoxycytidine triphosphate pyrophosphatase 1(dCTP pyrophosphatase 1, DCTPP1) is a newly discovered pyrophosphatase targeting deoxycytidine triphosphate (dCTP).
LI Jing, ZHANG Mei-gui, BAI Zhong-tian
doaj
5-Aza-2′-Deoxycytidine Regulates White Adipocyte Browning by Modulating miRNA-133a/Prdm16
Metabolites, 2022 The conversion of white adipocytes into brown adipocytes improves their thermogenesis and promotes energy consumption. Epigenetic modifications affect related genes and interfere with energy metabolism, and these are the basis of new ideas for obesity ...
Jia Liang +7 more
doaj +1 more source
Molecular Imaging of Deoxycytidine Kinase Activity Using Deoxycytidine-Enhanced CEST MRI [PDF]
Cancer Research, 2019 Abstract Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance.
Zheng, Han +6 more
openaire +2 more sources
Effects of DACT1 methylation status on invasion and metastasis of nasopharyngeal carcinoma
Biological Research, 2019 Background The purpose of the present study was to investigate the role of the methylation status of the DACT1 gene on the invasion and metastasis of nasopharyngeal carcinoma cells.
Ju-Hong Yang, Lie-Kun Lin, Song Zhang
doaj +1 more source
Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC-MS/MS. [PDF]
Biomed ChromatogrABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Deppas JJ +5 more
europepmc +2 more sources
Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. [PDF]
PLoS ONE, 2014 Efficient and adequate generation of deoxyribonucleotides is critical to successful DNA repair. We show that ataxia telangiectasia mutated (ATM) integrates the DNA damage response with DNA metabolism by regulating the salvage of deoxyribonucleosides ...
Yuri L Bunimovich +7 more
doaj +1 more source
Identification of novel DNA methylation inhibitors via a two-component reporter gene system
Journal of Biomedical Science, 2011 Background Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors azacytidine and 5-aza-2 ...
Chen Ching-Shih +9 more
doaj +1 more source