Results 31 to 40 of about 1,712 (131)
Alu element mutation spectra: Molecular clocks and the effect of DNA methylation [PDF]
, 2004 In primate genomes more than 40% of CpG islands are found within repetitive elements. With more than one million copies in the human genome, the Alu family of retrotransposons represents the most successful short interspersed element (SINE) in primates ...
Batzer, Mark A. +5 more
core +2 more sources
WIREs RNA, Volume 15, Issue 6, November/December 2024.CGG repeat expansion may occur in the 5′ untranslated region of the FMR1 gene. The resulting mutant DNA and RNA with expanded CGG repeats form stable secondary structures that can interfere with numerous cellular processes. Depending on the length of the CGG repeats, different molecular phenotypes may occur, which in turn determine different clinical ...
Izabela Broniarek +2 more
wiley +1 more source
FEBS Open Bio, Volume 8, Issue 12, Page 2022-2034, December 2018., 2018 Sulforaphane (SFN) may be a promising chemopreventive agent. We investigated the metabolic profiles of MCF‐7 cells with estrogen (E2) and/or SFN treatment by GC‐MS and UPLC‐Orbitrap‐MS methods. The data showed that SFN can reverse the E2‐induced changes in amino acid, purine, and folic acid metabolism, as well as glycolysis and energy metabolism, and ...
Shuyuan Cao +5 more
wiley +1 more source
DHODH: A Promising Target in the Treatment of T-Cell Acute Lymphoblastic Leukemia [PDF]
, 2023 Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) have a poor prognosis with few therapeutic options. With the goal of identifying novel therapeutic targets, we used data from the Dependency Map project to identify ...
Alexe, Gabriela +9 more
core +2 more sources
Photochemistry and Photobiology, Volume 100, Issue 6, Page 1698-1712, November/December 2024.UV photoexcitation of adjacent intra‐strand pyrimidines in DNA can promote their covalent dimerization at sites such as 5′‐T‐p‐T‐3′ and 5′‐T‐p‐C‐3′. This photo‐reactivity leads, notably, to cyclobutane pyrimidine dimers, pyrimidine (6‐4) pyrimidone photoproducts (6‐4PPs), and, in bacterial endospores, the spore photoproduct, SP.
Ritu Chaturvedi, Eric C. Long
wiley +1 more source
Risks for public health related to the presence of furan and methylfurans in food
EFSA Journal, Volume 15, Issue 10, October 2017., 2017 Abstract The European Commission asked EFSA for a scientific evaluation on the risk to human health of the presence of furan and methylfurans (2‐methylfuran, 3‐methylfuran and 2,5‐dimethylfuran) in food. They are formed in foods during thermal processing and can co‐occur.
EFSA Panel on Contaminants in the Food Chain (CONTAM) +29 more
wiley +1 more source
Chemistry – A European Journal, Volume 30, Issue 49, September 2, 2024.The mutagenic etheno adduct of guanine exhibits a peculiar behavior of its lowest singlet excited state. The two independent and short‐lived emission bands revealed by femtosecond upconversion fluorescence are associated with two strongly coupled bright minima of different geometry.
Paloma Lizondo‐Aranda +4 more
wiley +1 more source
Multiscale Systems‐Pharmacology Pipeline to Assess the Prophylactic Efficacy of NRTIs Against HIV‐1
CPT: Pharmacometrics &Systems Pharmacology, Volume 5, Issue 7, Page 377-387, July 2016., 2016 While HIV‐1 continues to spread, the use of antivirals in preexposure prophylaxis (PrEP) has recently been suggested. Here we present a modular systems pharmacology modeling pipeline, predicting PrEP efficacy of nucleotide reverse transcriptase inhibitors (NRTIs) at the scale of reverse transcription, target‐cell, and systemic infection and after ...
S Duwal, V Sunkara, M von Kleist
wiley +1 more source
Recognition of O6-benzyl-2′-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction [PDF]
, 2017 The 2′-deoxynucleoside containing the synthetic base 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)-1H-perimidin-2(3H)-one] (dPer) recognizes in DNA the O6-benzyl-2′-deoxyguanosine nucleoside (O6-Bn-dG), formed by exposure to N ...
Dhummakupt, Elizabeth +7 more
core
Multiple Factors Determine the Oncolytic or Carcinogenic Effects of TLRs Activation in Cancer
Journal of Immunology Research, Volume 2024, Issue 1, 2024.Toll‐like receptors (TLRs) belong to a germline‐encoded protein family. These are pattern recognition receptors. They sense pathogen‐associated molecular patterns (PAMPs). When this occurs, activation of the NF‐ĸB pathway follows. This triggers the innate immune response of the host.
Yingxiang Yang +4 more
wiley +1 more source