Results 131 to 140 of about 53,334 (334)

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang   +14 more
wiley   +1 more source

Data from <i>SLC43A3</i> Is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2′-Deoxyguanosine

open access: gold, 2023
Ilgen Mender   +8 more
openalex   +1 more source

Biomimetic Iridium‐Based Photothermal Nanozyme to Trigger Ferroptosis and Pyroptosis and Activate the cGAS‐STING Pathway for Improved Tumor Immunotherapy

open access: yesAdvanced Science, EarlyView.
This study develops an iridium‐based nanozyme (IIN@M) with superior enzyme‐like activity and photothermal performance. It disrupts intracellular redox balance by generating reactive oxygen species and depleting glutathione, which synergistically induces ferroptosis, pyroptosis, and immunogenic cell death.
Lijun Ding   +7 more
wiley   +1 more source

Effect of the tocotrienol-rich fraction on the lifespan and oxidative biomarkers in Caenorhabditis elegans under oxidative stress

open access: yesClinics, 2013
OBJECTIVE: This study was performed to determine the effect of the tocotrienol-rich fraction on the lifespan and oxidative status of C. elegans under oxidative stress.
Goon Jo Aan   +3 more
doaj  

Metabolomics reveals early pregnancy biomarkers in sows: a non-invasive diagnostic approach

open access: yesFrontiers in Veterinary Science
In an effort to enhance reproductive management and reduce non-productive periods in swine breeding, this study presents a novel, non-invasive metabolomics approach for the identification of early pregnancy biomarkers in sows.
Yujun Ren   +7 more
doaj   +1 more source

Formation and persistence of O6-(2-hydroxyethyl)-2′-deoxyguanosine in DNA of various rat tissues following a single dose of N-nitroso-N-(2-hydroxyethyl)urea. An immuno-slot-blot study [PDF]

open access: yes, 2017
Rabbit antibodies against O6-(2-hydroxyethyl)-2′-deoxyguanosine (O6-HEdG) were used to develop a highly sensitive immuno-slot-blot assay for this promutagenic base which enabled the quantitation of ≥ 3.6 μmol O6-HEdG/mol deoxy-guanosine, corresponding to
Kleihues, Paul, Ludeke, Barbara I.
core  

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

open access: yesAdvanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang   +7 more
wiley   +1 more source

Degradation of reactive red 195 by selected bacteria from textile wastewater [PDF]

open access: yes, 2009
Four selected bacterial strains coded R1, R2, Rc and Rd were successfully isolated from raw textile wastewater. They were screened for their ability to degrade an azo dye of Reactive Red 195 on solid and in liquid dye-containing media.
Nawahwi, Mohd. Zaini
core  

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

open access: yesAdvanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li   +7 more
wiley   +1 more source

Formation, Repair, and Genotoxic Properties of Bulky DNA Adducts Formed from Tobacco-Specific Nitrosamines

open access: yesJournal of Nucleic Acids, 2010
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N′-nitrosonornicotine (NNN) are tobacco-specific nitrosamines present in tobacco products and smoke.
Lisa A. Peterson
doaj   +1 more source

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