Results 231 to 239 of about 47,583 (239)

Interaction of Deoxyguanosine Nucleotide Analogs with Human Telomerase

Molecular Pharmacology, 2000
To maintain the telomeres at the ends of the chromosomes, telomerase in human cells adds a repeating sequence of nucleotides (TTAGGG) to the 3'-end of each chromosome using an RNA component of the enzyme as the template for DNA synthesis. Because of the selective expression of this enzyme in cancer cells, we have evaluated the interaction of human ...
Susan W. Tendian, William B. Parker
openaire   +3 more sources

Low enantioselectivities of human deoxycytidine kinase and human deoxyguanosine kinase with respect to 2'-deoxyadenosine, 2'-deoxyguanosine and their analogs

Biochimie, 1999
The antiviral activity of L-nucleoside analogs depends in part on the enantioselectivity of nucleoside kinases which catalyse their monophosphorylation. The substrate properties of human recombinant deoxycytidine kinase (dCK) and human recombinant deoxyguanosine kinase (dGK) with respect to L-adenosine and L-guanosine analogs, in the presence of ...
V. Boudou, Gilles Gosselin, Jean-Louis Imbach, Staffan Eriksson, G. Gaubert, Georges Maury   +5 more
openaire   +3 more sources

Mechanisms of Deoxyguanosine Toxicity for Human T and B Lymphocytes

1986
The discovery of a causal association between a deficiency of one of the enzymes of the purine degradative pathway and a selective cellular immunodeficiency has initiated studies on the relation of the purine/pyrimidine metabolism and lymphocyte function.
Sybe K. Wadman, Ger T. Rijkers, G. E. J. Staal, L. J. M. Spaapen, Ben J.M. Zegers, Scharenberg Jg   +5 more
openaire   +3 more sources

The reaction of guanosine and deoxyguanosine with glycidaldehyde

Tetrahedron Letters, 1968
T.P. Blazej, B. M. Goldschmidt, B. L. Van Duuren   +2 more
openaire   +3 more sources

On the Phosphorylation of Deoxyribonucleosides and the Protection of Deoxyguanosine

Bulletin des Sociétés Chimiques Belges, 1985
Etienne Sonveaux, H. Vermeersch, Pierre Francois, Yunxi Ma, G. Hamoir   +4 more
openaire   +2 more sources

Effect of Deoxyguanosine on Skeletal Development in the Chick Embryo [PDF]

Nature, 1966
Jean Spiggle, Louis J. Pierro
openaire   +3 more sources

Review for "Deoxyguanosine is a TLR7 agonist"

2019
openaire   +2 more sources

Blockade of DNA synthesis by the deoxyguanosine adducts N-(deoxyguanosin-8-yl)-4-acetylaminobiphenyl and N-(deoxyguanosin-8-yl)-4′-fluoro-4-acetylaminobiphenyl

Mutation Research/Environmental Mutagenesis and Related Subjects, 1991
J.H.N. Meerman, M.L.M. Van der Poll
openaire   +2 more sources

3'-Deoxynucleosides. III.¹ 3'-Deoxyguanosine

The Journal of Organic Chemistry, 1965
Edward Walton, Frederick W. Holly, Susan R. Jenkins   +2 more
openaire   +3 more sources