Results 21 to 30 of about 53,334 (334)
Nickel(II)-catalysed oxidative guanine and DNA damage beyond 8-oxoguanine [PDF]
, 2007 Oxidative DNA damage is one of the most important and most studied mechanisms of disease. It has been associated with a range of terminal diseases such as cancer, heart disease, hepatitis, and HIV, as well as with a variety of everyday ailments.
Kelly, Michele C. +3 more
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Photodynamic Reaction of Riboflavin and Deoxyguanosine [PDF]
Pediatric Research, 1981 Previous studies have demonstrated that phototherapy depresses serum riboflavin in jaundiced infants. The potential long-term hazards of this in vivo reaction may be significant in view of the in vitro reaction of riboflavin which modifies intracellular DNA in eukaryotic and prokaryotic cells.
J F, Ennever, W T, Speck
openaire +2 more sources
8-Oxo-deoxyguanosine: Reduce, reuse, recycle? [PDF]
Proceedings of the National Academy of Sciences, 2007 Despite a variety of antioxidant defenses, cellular production of oxidants such as reactive oxygen species leads to a background level of damage to the cell. Should the balance between oxidants and antioxidants shift in favor of the former, a condition of oxidative stress arises, which leads to widespread modification of molecules such as lipids and ...
Cooke, MS, Evans, MD
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Interaction of low-energy electrons with the purine bases, nucleosides, and nucleotides of DNA [PDF]
, 2006 The authors report results from computational studies of the interaction of low-energy electrons with the purine bases of DNA, adenine and guanine, as well as with the associated nucleosides, deoxyadenosine and deoxyguanosine, and the nucleotide ...
McKoy, Vincent, Winstead, Carl
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BioTechniques, 2016 The free nucleoside 2′-deoxyguanosine (dGuo) is the most susceptible to oxidation by reactive oxygen species (ROS) compared to the other free nucleosides, and its oxidation product 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) has been used as a ...
Patrícia S. Peres +2 more
doaj +1 more source
BMC Research Notes, 2020 Objective Owing to the overwhelming dominance of human and commensal microbe sequences, low efficiency is a major concern in clinical viral sequencing using next-generation sequencing.
Peng Peng +3 more
doaj +1 more source
Brain Sciences, 2021 Oxidative stress mechanisms may explain associations between perinatal acetaminophen exposure and childhood attention-deficit hyperactivity disorder (ADHD). We investigated whether the changes in umbilical cord plasma amino acids needed to synthesize the
Neha S. Anand +8 more
doaj +1 more source
Syntheses and characterizations of the in vivo replicative bypass and mutagenic properties of the minor-groove O2-alkylthymidine lesions. [PDF]
, 2014 Endogenous metabolism, environmental exposure, and treatment with some chemotherapeutic agents can all give rise to DNA alkylation, which can occur on the phosphate backbone as well as the ring nitrogen or exocyclic nitrogen and oxygen atoms of ...
Cai, Qian +3 more
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Oligonucleotide Incorporation of 8-Thio-2‘-deoxyguanosine [PDF]
Organic Letters, 2004 [reaction: see text] 8-Thio-2'-deoxyguanosine (SdG) is a useful analogue of the abundant promutagen 8-oxo-2'-deoxyguanosine (OdG). Its synthesis and DNA incorporation using standard phosphoramidite chemistry is reported. To prevent oxidation during DNA synthesis, the sulfur was protected as a 2-(trimethylsilyl)ethyl sulfide.
Michelle L, Hamm +3 more
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Separation of oxidatively damaged DNA Nucleobases and Nucleosides on Packed and Monolith C18 Columns by HPLC-UV-EC [PDF]
, 2008 This study involves the incorporation of a commercially available Phenomenex Onyx C18 monolith column into the separation and detection of oxidative DNA damage.
Kelly, Michele C. +2 more
core +1 more source