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Acta Crystallographica Section C Crystal Structure Communications, 2005
In the title compound, 2-amino-7-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one, C11H14N4O4, the N-glycosylic bond torsion angle, chi, is anti [-106.5 (3) degrees ]. The 2'-deoxyribofuranosyl moiety adopts the 3T4 (N-type) conformation, with P = 39.1 degrees and tau(m) = 40.3 degrees .
Frank, Seela +2 more
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In the title compound, 2-amino-7-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,7-dihydropyrrolo[2,3-d]pyrimidin-4-one, C11H14N4O4, the N-glycosylic bond torsion angle, chi, is anti [-106.5 (3) degrees ]. The 2'-deoxyribofuranosyl moiety adopts the 3T4 (N-type) conformation, with P = 39.1 degrees and tau(m) = 40.3 degrees .
Frank, Seela +2 more
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Deoxyguanosine kinase from human placenta
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1982Deoxyguanosine kinase (ATP:deoxyguanosine 5'-phosphotransferase) has been purified up to a specific activity of 10.3 nmol/min per mg protein from human placenta. The enzyme appears to have a molecular weight of 58 000 from the results of Sephadex G-75 gel filtration.
Y, Yamada, H, Goto, N, Ogasawara
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Mass spectrometric quantitation of deoxyguanosine and leukotriene A4-deoxyguanosine adducts of DNA
Analytical Biochemistry, 2004An assay was developed using electrospray ionization negative ion tandem mass spectrometry (MS) to identify and quantitate the major product in the reaction of leukotriene A(4) (LTA(4)) with deoxyguanosine (dGuo). A second quantitative assay was established using the same separation and detection techniques to determine the amount of dGuo isolated from
Joseph A, Hankin, Robert C, Murphy
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Regioselective 1‐Alkylation of 2′‐Deoxyguanosine.
ChemInform, 2002AbstractFor Abstract see ChemInform Abstract in Full Text.
Yanhe, Huang, Francis, Johnson
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Solution Structure of a DNA Duplex Containing 8-Hydroxy-2′-Deoxyguanosine Opposite Deoxyguanosine
Journal of Molecular Biology, 2003Deoxyguanosine residues are hydroxylated by reactive oxygen species at the C-8 position to form 8-hydroxy-2'-deoxyguanosine (8-OG), one of the most important mutagenic lesions in DNA. Though the spontaneous G:C to C:G transversions are rare events, the pathways leading to this mutation are not established.
Varatharasa, Thiviyanathan +4 more
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Antibodies specific to deoxyguanosine 5′-phosphate
Molecular Immunology, 1980Abstract Antibodies to deoxyguanosine 5′-phosphate were produced in rabbits using a bovine serum albumin conjugate of the nucleotide. The presence of hapten-specific antibodies in the antisera was shown by double diffusion in agar and the quantitative precipitin reaction. The specificity of the antibodies was determined by measuring the inhibition of
K, Jayaraman, T M, Jacob
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Chemical Research in Toxicology, 1996
The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4-C5 double bond of 2'-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine (nox-dG).
Douki, Thierry, Cadet, J., Ames, B. N.
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The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4-C5 double bond of 2'-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine (nox-dG).
Douki, Thierry, Cadet, J., Ames, B. N.
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Modification of deoxyguanosine by chloroethylene oxide
Carcinogenesis, 1981Reaction of deoxyguanosine in glacial acetic acid with chloroethylene oxide, a proposed reactive metabolite of vinyl chloride, led to a single, strongly fluorescent product in nearly quantitative yield. The u.v. spectra indicated alkylation of N-7 of guanine, which was confirmed following reduction of the reaction product by sodium borohydride to 7-(2 ...
E, Scherer +4 more
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Molecular conformation of deoxyguanosine 5′-phosphate
Nature, 1974THE allowed conformations of nucleic acids depend on the flexibility of the structure of the nucleotides from which they are constructed. Many X-ray crystallographic studies of the degree of flexibility of these structures have shown that nucleosides exhibit a larger number of preferred conformations than nucleotides, and this led Sundaralingam1 to ...
D W, Young, P, Tollin, M R, Wilson
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