Results 311 to 320 of about 53,334 (334)

The role of metal ion binding in generating 8-hydroxy-2′-deoxyguanosine from the nucleoside 2′-deoxyguanosine and the nucleotide 2′-deoxyguanosine-5′-monophosphate

Journal of Inorganic Biochemistry, 2007
The metal ions Cu(II), Fe(II), and Cr(III) were allowed to react with H(2)O(2) in the presence of either the mononucleoside 2'-deoxyguanosine (dG) or the mononucleotide 2'-deoxyguanosine-5'-monophosphate (dGMP). The percentage of reacted dG or dGMP that formed the oxidative damage marker 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was monitored.
Noblitt, Scott D., Huehls, A. M., Morris, Daniel   +2 more
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Hydroxyl-specific fluorescence labeling of ABP-deoxyguanosine, PhIP-deoxyguanosine, and AFB1-formamidopyrimidine with BODIPY-FL

Analytical Biochemistry, 2006
Detection and analysis of DNA adducts resulting from endogenous or exogenous exposures to carcinogens are essential not only for quantifying biologically effective doses but also for establishing relationships between exposure and cancer risk. We have developed and validated a procedure of high sensitivity and specificity based on fluorescence labeling
Hyun Gyung, Jang, Misun, Park, John S, Wishnok, Steven R, Tannenbaum, Gerald N, Wogan   +4 more
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Structure of a neothramycin-2′-deoxyguanosine adduct

Biochemical and Biophysical Research Communications, 1981
Abstract The interaction of neothramycin, a pyrrolo (1,4)benzodiazepine antibiotic with antitumor activity, with deoxyribonucleosides was studied as a model of the drug-DNA binding. The antibiotic was demonstrated to react with 2′-deoxyguanosine in aqueous dimethyl sulfoxide. Two reaction products were found on thin-layer plates.
I N, Maruyama, N, Tanaka, S, Kondo, H, Umezawa   +3 more
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Deoxyguanosine kinase of neonatal mouse skin tissue

Biochimica et Biophysica Acta (BBA) - Enzymology, 1981
Deoxyguanosine kinase (ATP: deoxyguanosine 5'-phosphotransferase) activity has been identified in neonatal mouse skin tissue. This activity which has a molecular weight of 44 000 was shown to be highly specific for deoxyguanosine as a substrate. Unique to deoxynucleoside kinases was the observation that this enzyme possessed a pH optimum of 5.2.
J, Barker, R A, Lewis
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Characterization of a Deoxyguanosine Adduct of Tetrachlorobenzoquinone:  Dichlorobenzoquinone-1,N²-etheno-2‘-deoxyguanosine

Chemical Research in Toxicology, 2005
Pentachlorophenol (PCP), a widespread environmental pollutant that is possibly carcinogenic to humans, is metabolically oxidized to tetrachloroquinone. DNA adducts attributable to tetrachloroquinone have been observed previously in vitro and detected in vivo. In addition, an unidentified adduct in these studies coeluted with the product of the reaction
Thu N T, Nguyen, Anthony D, Bertagnolli, Peter W, Villalta, Philippe, Bühlmann, Shana J, Sturla   +4 more
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Synthesis and characterization of deoxyguanosine–benzoquinone adducts

Journal of Applied Toxicology, 1990
AbstractBenzene expresses its carcinogenic potential in humans largely in the form of acute leukemia. Because an understanding of the formation of DNA adducts by benzene metabolites may help to explain the etiologkal role they play in benzene‐induced bone marrow disease, we have synthesized, isolated and characterized adducts formed by the reaction of ...
L, Jowa, G, Witz, R, Snyder, S, Winkle, G F, Kalf   +4 more
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Deoxyguanosine kinase deficiency presenting as neonatal hemochromatosis

Molecular Genetics and Metabolism, 2011
Mutations in DGUOK result in mitochondrial DNA (mtDNA) depletion and may present as neonatal liver failure. Neonatal hemochromatosis (NH(1)) is a liver disorder of uncertain and varied etiology characterized by hepatic and non-reticuloendothelial siderosis.
Neil A, Hanchard, Oleg A, Shchelochkov, Angshumoy, Roy, Joanna, Wiszniewska, Jing, Wang, Edwina J, Popek, Saul, Karpen, Lee-Jun C, Wong, Fernando, Scaglia   +8 more
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Phosphorylation of Deoxyguanosine in Rat Liver Mitochondria

1984
Recent studies document that mitochondria from mouse skin (1), human lung fibroblasts (2) and calf thymus (3) contain a deoxyguanosine (dG) kinase which is distinctly different from that found in the cytosol. A preliminary report (4) has shown that dG is taken up by intact, respiring rat liver mitochondria by a carrier mediated process.
R A, Lewis, L F, Watkins
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Deoxyguanosine Adducts Formed from Benzoquinone and Hydroquinone

1986
The mechanism by which benzene produces bone marrow damage is not known with certainty, but it is generally accepted that the toxicity is mediated by one or more benzene metabolites. Radiolabeled metabolites of benzene administered in vivo have been shown to covalently bind to DNA in rat liver (Lutz and Schlatter, 1977) and mouse bone marrow (Gill and ...
L, Jowa, S, Winkle, G, Kalf, G, Witz, R, Snyder   +4 more
openaire   +2 more sources

Mitochondrial deoxyribonucleotide pools in deoxyguanosine kinase deficiency

Molecular Genetics and Metabolism, 2008
Mutated deoxyguanosine kinase (dGK), which catalyses the first step of the mitochondrial deoxypurine salvage pathway, accounts for a hepatocerebral variant of mitochondrial DNA (mtDNA) depletion syndromes. In order to elucidate the pathogenic mechanism of dGK deficiency, mitochondrial and cytoplasmic deoxyribonucleoside triphosphate (dNTP) pools in ...
openaire   +2 more sources