Results 31 to 40 of about 53,334 (334)

Synthesis of 8-Heteroaryl-2′-deoxyguanosine Derivatives [PDF]

Synlett, 2008
We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2'-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.
Hobley, G., Gubala, V., Rivera-Sánchez, M.D.C., Rivera, J.M.   +3 more
openaire   +3 more sources

Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance [PDF]

, 2010
Glyoxal and methylglyoxal are reactive dicarbonyl metabolites formed and metabolized in physiological systems. Increased exposure to these dicarbonyls is linked to mutagenesis and cytotoxicity and enhanced dicarbonyl metabolism by overexpression of ...
Baynes, Boyum, Brigitte M. Winklhofer-Roob, Cao, Cao, Chan, Chung, Cooke, Cooke, De Bont, Dobler, Duewelhenke, Fleming, Frischmann, Gatenby, Hou, Kang, Krymkiewicz, Larisch, Li, Luo, Michael R. Stratton, Morcos, Naila Rabbani, Nicolay, Papoulis, Paul J. Thornalley, Pfaffl, Pischetsrieder, Rock, Sahar Waris, Sakamoto, Sakamoto, Sarah J. Larkin, Schneider, Seidel, Shapiro, Synold, Thomas Fleming, Thomas Santarius, Thornalley, Thornalley, Thornalley, Thornalley, Thornalley, Vaca, Wang, Yeluri, Yuan   +48 more
core   +2 more sources

The role of some oxidative stress and inflammatory factors in essential hypertension [PDF]

Zanco Journal of Medical Sciences, 2018
Background and Objective: Oxidative stress and inflammation are cooperative events involved in essential hypertension development. This study aimed to evaluate the association of N-terminal pro-Brain natriuretic peptide, matrix-metalloprotinase-9 and 8 ...
Julian Yonan Ismaeil, Shatha Rouf Moustafa   +1 more
doaj   +1 more source

Discovery of a novel nucleoside immune signaling molecule 2′-deoxyguanosine in microbes and plants

Journal of Advanced Research, 2023
Introduction: Beneficial microorganisms play essential roles in plant growth and induced systemic resistance (ISR) by releasing signaling molecules. Our previous study obtained the crude extract from beneficial endophyte Paecilomyces variotii, termed ZNC
Chongchong Lu, Qingbin Wang, Yanke Jiang, Min Zhang, Xuanlin Meng, Yang Li, Baoyou Liu, Ziyi Yin, Haifeng Liu, Chune Peng, Fuchuan Li, Yingzhe Yue, Mingxia Hao, Yurong Sui, Lulu Wang, Guodong Cheng, Jianzhu Liu, Zhaohui Chu, Changxiang Zhu, Hansong Dong, Xinhua Ding   +20 more
doaj   +1 more source

Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation. [PDF]

, 2016
Inadequate dietary Zn consumption increases susceptibility to esophageal and other cancers in humans and model organisms. Since Zn supplementation can prevent cancers in rodent squamous cell carcinoma (SCC) models, we were interested in determining if it
Druck, Teresa, Fong, Louise Y., Huebner, Kay, Liu, James, Pan, Xueliang, Quimby, Donald, Schrock, Morgan S., Shen, Rulong, Sun, Jin, Zanesi, Nicola   +9 more
core   +2 more sources

Early-life adversity accelerates cellular ageing and affects adult inflammation: experimental evidence from the European starling [PDF]

, 2017
Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter ...
Andrews, Clare, Bateson, Melissa, Bedford, Tom, Kolenda, Claire, Martin-Ruiz, Carmen, Monaghan, Patricia, Nettle, Daniel, Parker, Craig, Reichert, Sophie   +8 more
core   +4 more sources

Biotinylation of Deoxyguanosine at the Abasic Site in Double-Stranded Oligodeoxynucleotides

Journal of Analytical Methods in Chemistry, 2016
Biotinylation of deoxyguanosine at an abasic site in double-stranded oligodeoxynucleotides was studied. The biotinylation of deoxyguanosine is achieved by copper-catalyzed click reaction after the conjugation of the oligodeoxynucleotide with 2-oxohex-5 ...
Chun Wu
doaj   +1 more source

Investigation of the Effects of L-carnitine and magnesium on Oxidative Stress and Cytokines in the Tissue of Experimental diabetic rats

Acta Veterinaria, 2021
The aim of this study was to determine the effects of L-carnitine and magnesium on the levels of tissue malondialdehyde, 8-hydroxy-2’-deoxyguanosine, and cytokines (tumor necrosis factor alpha, interleukin-6) in streptozotocin-induced experimental ...
Senturk Meryem, Eren Meryem, Sarica Zeynep Soyer   +2 more
doaj   +1 more source

Crystal structure of the nucleoside 2′-deoxyguanosine dimethyl sulfoxide disolvate

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compound, C10H13N5O4·2C2H6OS, which is of interest with respect to its biological activity, at 183 K has orthorhombic (P212121) crystal symmetry. The structure displays a network of intermolecular N—H...N, N—H...O and O—H...O hydrogen bonds. 2′-
Bernhard Spingler
doaj   +1 more source

Genome-wide gene expression analysis of anguillid herpesvirus 1 [PDF]

, 2013
<p>Background: Whereas temporal gene expression in mammalian herpesviruses has been studied extensively, little is known about gene expression in fish herpesviruses.
Davison, A.J., Engelsma, M.Y., Peeters, B.P.H., Rottier, P.J.M., van Beurden, S.J.   +4 more
core   +3 more sources