Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. [PDF]
, 2019 People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults.
Boss, Gerry R +15 more
core +1 more source
Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury [PDF]
, 2019 TonEBP (tonicity-responsive enhancer binding protein) is a transcriptional regulator whose expression is elevated in response to various forms of stress including hyperglycemia, inflammation, and hypoxia.
Choi, Soo Youn +10 more
core +1 more source
Discovery of a novel nucleoside immune signaling molecule 2′-deoxyguanosine in microbes and plants
Journal of Advanced Research, 2023 Introduction: Beneficial microorganisms play essential roles in plant growth and induced systemic resistance (ISR) by releasing signaling molecules. Our previous study obtained the crude extract from beneficial endophyte Paecilomyces variotii, termed ZNC
Chongchong Lu +20 more
doaj
Genomic 8-oxo-7,8-dihydro-2'-deoxyguanosine Quantification
Bio-Protocol, 2013 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) is among the most common reactive oxygen species-induced DNA lesions and can be used as a biomarker for oxidative stress.
Antonio Sarno
doaj +1 more source
Effect of Pycnogenol® on attention-deficit hyperactivity disorder (ADHD) : study protocol for a randomised controlled trial [PDF]
, 2017 Background: Methylphenidate (MPH), the first choice medication for attention-deficit hyperactivity disorder (ADHD), is associated with serious adverse effects like arrhythmia.
Ceulemans, Berten +7 more
core +2 more sources
Hepatocerebral Mitochondrial DNA Depletion
Pediatric Neurology Briefs, 2005 Two novel homozygous mutations, G352A and C269T, are documented in the gene for deoxyguanosine kinase (DGK) in 3 children with hepatocerebral mitochondrial DNA depletion syndrome reported from Columbia University College of Physicians and Surgeons, New ...
J Gordon Millichap
doaj +1 more source
For MutY, It's All about the OG [PDF]
, 2012 MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with the oxidatively modified form of deoxyguanosine, 8-oxo-7,8-dihydro-2′-deoxyguanosine. In a recent issue of Chemistry & Biology, Brinkmeyer et al.
Sobol, Robert W.
core +1 more source
Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols [PDF]
, 2009 Inflammatory bowel diseases (IBD) are immunomediated ailments affecting millions of individuals. Although diet is regarded as an important factor influencing IBD, there are no accepted dietary recommendations presently available.
Baron, A. +18 more
core +2 more sources
Тонкие химические технологии, 2010 The article presents an optimized method for the determination of the ratio of 8-oxo-2'-deoxyguanosine (formed in DNA due to the action of active forms of oxygen) to 2'-deoxyguanosine.
D. S. Esipov +7 more
doaj
Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB [PDF]
, 2014 The structurally related exocyclic guanine adducts α-hydroxypropano-dG (α-OH-PdG), γ-hydroxypropano-dG (γ-OH-PdG), and M[subscript 1]dG are formed when DNA is exposed to the reactive aldehydes acrolein and malondialdehyde (MDA).
Delaney, James C. +8 more
core +3 more sources