Results 81 to 90 of about 53,334 (334)

G Quadruplexes Stabilised by 8‐Oxo‐2′‐deoxyguanosine [PDF]

Chemistry – A European Journal, 2011
G quadruplexes (GQPs) are four-stranded secondary structures formed of guanosine-rich nucleic acids. They consist of at least two G tetrads composed of four guanosine nucleotides. DNA GQPs have been shown to fold into a variety of different topologies that can be divided into antiparallel and parallel conformations (the latter is depicted in Figure 1 A)
Singh, Vijay, Benz, Armin, Hartig, Jörg S.   +2 more
openaire   +3 more sources

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Ab-initio study of model guanine assemblies: The role of pi-pi coupling and band transport

, 2001
Several assemblies of guanine molecules are investigated by means of first-principle calculations. Such structures include stacked and hydrogen-bonded dimers, as well as vertical columns and planar ribbons, respectively, obtained by periodically ...
A. Aviram, A. D. Becke, Anna Garbesi, Arrigo Calzolari, B. Giese, C. Joachim, C. Lee, D. Porath, E. Braun, E. Meggers, Elisa Molinari, F. D. Lewis, G. B. Schuster, G. Gottarelli, G. Gottarelli, H. J. Monkhorst, H. Sugiyama, H.-W. Fink, J. Hutter, J. Jortner, J. Šponer, J. Šponer, K. Nakatani, L. Kleinman, M. Bixon, M. Bockstedte, M. W. Grinstaff, N. Troullier, P. F. Barbara, P. Gomes Da Costa, P. Hobza, P. J. de Pablo, R. A. Marcus, R. Car, R. Rinaldi, R. Taylor, Rosa Di Felice, S. K. Pugh, Y. Okahata, Y.-J. Ye, Y.-J. Ye   +40 more
core   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

8-Oxo-7,8-dihydro-2′-deoxyguanosine values measured in brain DNA of rats upon investigating cortexin protective action

Тонкие химические технологии, 2012
The protective effect of cortexin was investigated with the use of acoustic stress hemorrhagic stroke model. A significant decrease of 8-oxo-2'-deoxyguanosine to 2'-deoxyguanosine ratio in the DNA molecule was shown using brain slices of cortexin treated
D. S. Esipov, O. V. Esipova, T. V. Zinevich, T. A. Gorbacheva, T. S. Nevredimova, A. L. Krushinsky, V. S. Kuzenkov, V. P. Reutov   +7 more
doaj  

Drug‐Free Thrombolysis Mediated by Physically Activated Micro/Nanoparticles

Advanced Functional Materials, EarlyView.
Overview of particle‐mediated thrombolytic effects (thermal, mechanical, and chemical) and their activating physical stimuli (light, ultrasound, and magnetic field) in drug‐free thrombolysis. ABSTRACT Thrombus‐associated disorders rank among the world's leading causes of death, with ischemic heart disease and stroke as the main contributors.
Pierre Sarfati, Yoann Lalatonne, Cédric Chauvierre   +2 more
wiley   +1 more source

Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes [PDF]

, 2018
Growing evidence shows that improper intake of vitamin B6 increases cancer risk and several studies indicate that diabetic patients have a higher risk of developing tumors.
MF Fenech, M Fenech, F Mitelman, A Aguilera, SF Bunting, SJ Duthie, MJ Shrubsole, YI Kim, JB Mason, CD Cantarella, R Percudani, R Percudani, ML Salvo di, H Hellmann, AA Booth, P Bilski, SA Denslow, BN Ames, L Galluzzi, S Mocellin, L Galluzzi, B Gylling, A Marzio, P Kanellis, SC Lee, M Brownlee, D Bonnefont-Rousselot, Y Hinokio, MT Goodarzi, E Tatsch, P Graham, RS Garofalo, RW Alfa, LP Musselman, SN Thompson, R Ugrankar, R Bohni, M Tatar, JM Murillo-Maldonado, M Lorenzi, A Rezabakhsh, SE Polo, JP Madigan, PA Jeggo, C Merigliano, H Vlassara, H Stopper, N Schupp, S Golbidi, EA Muellenbach, J Colombani, AT Haselton, SK Kim, G Lee, EJ Rulifson, SJ Broughton, T Ikeya, M Fraser, S Nakamura, M Pischetsrieder, S Nakamura, J Blasiak, PT Clayton, M Okada, JE Leklem, HJ Ahn, WA Nix, M Gatti, S Bonaccorsi, FJ Diaz-Benjumea   +69 more
core   +2 more sources

Azaporphyrinoid‐Based Photo‐ and Electroactive Architectures for Advanced Functional Materials

Advanced Materials, EarlyView.
A long‐standing collaboration between the Torres and Guldi groups has yielded diverse azaporphyrinoid‐based donor‐acceptor nanohybrids with promising applications in solar energy conversion. This conspectus highlights key molecular platforms and structure‐function relationships that govern light and charge management, supporting the rational design of ...
Jorge Labella, Kobra Azizi, Dirk M. Guldi, Tomás Torres   +3 more
wiley   +1 more source

Determination of 8-hydroxy-2'-deoxyguanosine in urine by UHPLC-MS/MS

Zhiye weisheng yu yingji jiuyuan
Objective To establish a ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/ MS) method for the detection of 8-hydroxy-2'-deoxyguanosine in urine, providing methodological support for the quantitative assessment of DNA ...
ZHAO Tengwen
doaj   +1 more source

Protective Effects of Myricetin on Benzo[a]pyrene-Induced 8-Hydroxy-2′-Deoxyguanosine and BPDE-DNA Adduct

Antioxidants, 2020
Benzo[a]pyrene (B[a]P), a group 1 carcinogen, induces mutagenic DNA adducts. Myricetin is present in many natural foods with diverse biological activities, such as anti-oxidative and anti-cancer activities.
Seung-Cheol Jee, Min Kim, Kyeong Seok Kim, Hyung-Sik Kim, Jung-Suk Sung   +4 more
doaj   +1 more source