Results 61 to 70 of about 159,619 (187)

Active Site of Deoxyribonuclease I . III. Effects of Radiation on Deoxyribonuclease I in Dry State [PDF]

Journal of Radiation Research, 1963
The mechanisms of inactivation of deoxyribonuclease by direct action of radiation have been studied. By testing kinetic properties of the enzyme and its tryptophan content, it seems likely that when the enzyme molecule absorbs energy from radiation, the energy is transferred to the ‘active site’ of the enzyme.
openaire   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source

Degradation of RNA during lysis of Escherichia coli cells in agarose plugs breaks the chromosome. [PDF]

PLoS ONE, 2017
The nucleoid of Escherichia coli comprises DNA, nucleoid associated proteins (NAPs) and RNA, whose role is unclear. We found that lysing bacterial cells embedded in agarose plugs in the presence of RNases caused massive fragmentation of the chromosomal ...
Sharik R Khan, Andrei Kuzminov
doaj   +1 more source

Association of Nasal and Inhalant Corticosteroids With Pediatric Perioral Dermatitis: A TriNetX Retrospective Cohort Study

Pediatric Dermatology, EarlyView.
ABSTRACT Although topical corticosteroids are known triggers in the development of perioral dermatitis (PD), investigation into inhalant and nasal corticosteroid preparations, commonly used to manage allergic rhinitis and asthma, remains limited to case series.
Taylor Merkle, Caitlyn Curley, Dylan Wambold, Basira Iginla, Erum N. Ilyas   +4 more
wiley   +1 more source

Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients

Trials, 2020
Background Acute respiratory distress syndrome continues to drive significant morbidity and mortality after severe trauma. The incidence of trauma-induced, moderate-to-severe hypoxaemia, according to the Berlin definition, could be as high as 45%.
Julien Pottecher, Eric Noll, Marie Borel, Gérard Audibert, Sébastien Gette, Christian Meyer, Elisabeth Gaertner, Vincent Legros, Raphaël Carapito, Béatrice Uring-Lambert, Erik Sauleau, Walter G. Land, Seiamak Bahram, Alain Meyer, Bernard Geny, Pierre Diemunsch   +15 more
doaj   +1 more source

Circulating Level of Neutrophil Extracellular Traps Is Not a Useful Biomarker for Assessing Disease Activity in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. [PDF]

PLoS ONE, 2016
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of life-threatening disorders, and frequently affects the kidneys.
Huan Wang, Li-Li Sha, Tian-Tian Ma, Lu-Xia Zhang, Min Chen, Ming-Hui Zhao   +5 more
doaj   +1 more source

Effects of photobiomodulation therapy on pulmonary inflammation in chronic asthma: Dosimetric study in an experimental model

Photochemistry and Photobiology, EarlyView.
Photobiomodulation therapy (PBMT) was evaluated across a radiant energy range (1–7.5 J) in a murine model of chronic ovalbumin‐induced asthma to identify the optimal therapeutic dose. PBMT attenuated airway inflammation and remodelling, suppressed Th2 cytokines, and enhanced regulatory immune responses, highlighting a dose‐dependent immunomodulatory ...
Tawany Gonçalves Santos, Cintia Estefano Alves, Aurileia Aparecida de Brito, Bibiana Padilha de Menezes da Silva, Cinthya Cosme Gutierrez Duran, Stella Zamuner, Rodrigo Labat, José Antonio Silva Junior, Maria Cristina Chavantes, Flavio Aimbire, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira   +11 more
wiley   +1 more source

The protective effect of DNase I in retinal vein occlusion

Biomolecules & Biomedicine
Retinal vein occlusion (RVO) ranks as the second most prevalent retinal vascular disease, following diabetic retinopathy. Neutrophil extracellular traps (NETs) play an important role in vascular diseases.
Guohua Deng, Xi Zou, Zhinan Liu, Hang Ren, Yanting Li, Bin Chen, Jun Zhang   +6 more
doaj   +1 more source

Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions

MedComm, Volume 7, Issue 7, July 2026.
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An, Yi An, Mengwei Chen, Longlong Wu, Rong Wang   +4 more
wiley   +1 more source

Self‐Assembled Nanocomplexes of Oligomerized Catechins and Deoxyribonuclease‐I for Synergistically Enhancing Diabetic Wound Healing

Aggregate
Diabetic ulcers (DUs), a severe complication of diabetes, are characterized by impaired wound healing and contribute significantly to morbidity and mortality.
Yue Li, Yuye Yang, Huiying Zhang, Rongshuang Xin, Xinyi Pang, Tianxin Li, Wei Liu, Xin Zhou, Zinuo Zhang, Sailong Wang, Xinwei Miao, Jie Dong, Yan Zheng, Zhigui Su, Jun Chen, Mei Dong   +15 more
doaj   +1 more source