Results 71 to 80 of about 159,619 (187)

PolyGraph – Flexible, Biocompatible & Electrically Optimized Graphene‐Polymer Composites for Next‐Generation Neural Interfaces

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
PolyGraph, a flexible graphene‐polycaprolactone nanocomposite, unites conductivity, biocompatibility, and processability for next‐generation neural interfaces. Fabricated into microneedle arrays with ultra‐flexible backings, PolyGraph enables bidirectional neuronal recording and stimulation in brain tissue, advancing brain‐computer interface (BCI) and ...
Jack Maughan, Ian Woods, Cian O'Connor, Pablo Quintana‐Sarti, Eoin Caffrey, Jose M. Munuera, Tian Carey, Adrian Dervan, Alejandro López Valdés, Omar Mamad, Maeve A. Caldwell, Fergal J. O'Brien, Jonathan N. Coleman   +12 more
wiley   +1 more source

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, Volume 38, Issue 34, 17 June 2026.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

Advanced Science, Volume 13, Issue 31, 4 June 2026.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim, Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Jeongha Lee, Yoon Ji Jeong, Gyu Tae Park, Seongdo Jeong, Ki Won Hwang, Murim Choi, Jinhong Shin, Suck Won Hong, Jae Ho Kim   +12 more
wiley   +1 more source

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Multifunctional nano-delivery system based on DNase I and photodynamic therapy for combatting enterococcus faecalis biofilm infections

Scientific Reports
Persistent or refractory apical periodontitis is primarily caused by microbial retention, as conventional root canal treatment often fails to eliminate infections completely, and systemic antibiotic therapy is insufficient to achieve effective ...
Meng Xia, Shisheng Cao, Zeqi Liu, Jiakang Zhao, Yibo Yuan, Jianhui Ni, Zhengjian Guo, Weihan Wang, Huijuan Yin, Zhaohui Zou   +9 more
doaj   +1 more source

Characterization of extracellular polymeric matrix, and treatment of Fusobacterium nucleatum and Porphyromonas gingivalis biofilms with DNase I and proteinase K

Journal of Oral Microbiology, 2013
Background: Biofilms are organized communities of microorganisms embedded in a self-produced extracellular polymeric matrix (EPM), often with great phylogenetic variety. Bacteria in the subgingival biofilm are key factors that cause periodontal diseases;
Marwan Mansoor Ali Mohammed, Audun H. Nerland, Mohammed Al-Haroni, Vidar Bakken   +3 more
doaj   +1 more source

Multi‐omics analysis identifies a major histocompatibility complex class II‐associated antigen‐presenting cancer‐associated fibroblast‐like state linked to the nuclear factor erythroid 2‐related factor 2‐karyopherin subunit beta 1 axis in nonsmall cell lung cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
NSCLC contains an MHC‐II‐associated antigen‐presenting CAF‐like (apCAF‐like) state regulated by the NRF2‐KPNB1 axis. NRF2/KPNB1 signaling suppresses CIITA‐dependent antigen presentation and T‐cell activation, whereas inhibition of this pathway enhances antitumor immunity and improves responsiveness to anti‐PD‐1 therapy.
Fei Zheng, Ruoying Deng, Ran Hou, Lei Hong, Yanzhi Cui, Yibing Liu   +5 more
wiley   +1 more source

3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from an Australian Sea Salt Fungal Strain

Marine Drugs, 2009
We isolated a pol inhibitor from the cultured mycelia extract of a fungal strain isolated from natural salt from a sea salt pan in Australia, which was identified as 3-O-methylfunicone by spectroscopic analyses.
Fumio Sugawara, Hiromi Yoshida, Ken Hirano, Toshifumi Takeuchi, Yasuhiro Yamaguchi, Yoshiyuki Mizushina, Hirohisa Motoshima   +6 more
doaj   +1 more source

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source

MccB‐catalyzed C‐terminal Thioesterification for Protein Bioconjugation

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Protein bioconjugation enables the installation of functional groups, probes, and payloads that cannot be genetically encoded, thereby enabling the study and manipulation of biological systems. An important class of intermediates in protein bioconjugation is C‐terminal protein α‐thioesters, which are kinetically stable yet thermodynamically ...
Di Yang, Amy M. Weeks
wiley   +1 more source