Protein Science, Volume 35, Issue 6, June 2026.Abstract Lipopolysaccharides (LPS) are the principal chemical component of the outer leaflet of Gram‐negative bacteria and constitute the first barrier of defense against foreign molecules. Inhibition of LPS transport presents a novel concept for antibiotic discovery, and components of the transport bridge are targets of antimicrobial peptides. LptD, a
Wenzhao Dai +5 more
wiley +1 more source
Atypical Tetracyclines Promote Longevity and Ferroptotic Neuroprotection via Translation Attenuation
Aging Cell, Volume 25, Issue 6, June 2026.Tetracyclines extend lifespan and protect neurons from ferroptosis by attenuating protein synthesis across multiple eukaryotic models through ISR‐dependent or ISR‐independent mechanisms, enabling classification based on their mode of action. ABSTRACT Reducing protein synthesis extends lifespan across taxa, but pharmacological strategies to safely ...
Khalyd J. Clay +8 more
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Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Ischemic insult causes hyper‐glutamatergic signaling and neuronal death. The astrocytic transporter GLT‐1, which clears extracellular glutamate, is internalized and degraded in response to ischemia. We found that lysine‐directed post‐translational modifications (particularly ubiquitination) of the C‐terminal domain drive aberrant trafficking ...
Simran Kaur Gill +4 more
wiley +1 more source
Correction: A fluorescent biosensor for cardiac biomarker myoglobin detection based on carbon dots and deoxyribonuclease I-aided target recycling signal amplification. [PDF]
RSC Adv, 2022 Chen J +7 more
europepmc +1 more source
The role of NETosis in breast cancer: mechanistic insights and biomarker potential
Breast Cancer ResearchNeutrophil extracellular trap formation (NETosis), previously described as an effector host defense mechanism, is more frequently associated with cancer-driven inflammation and tumor development. In the case of breast cancer, NETosis assists with several
Fahimeh Norouzi +2 more
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Studies on Silkworm Deoxyribonuclease I. Part III
Journal of the agricultural chemical society of Japan, 1960 Sp-DNAのS-DNase I消化物のうち約46%は蒸溜水に対して非透析性の所謂“Core”分劃である.本分劃に就いてWyatt(8)の方法によって塩基組成,アデニン:グアニン:シトシン:チミン=29.5:21.5:20.3:28.6 (モル百分率)を求め,又末端燐酸基の定量的除去にボスホモノエステラーゼを用いる事により末端基法によって平均重合度約4.6という値を得,両値から平均分子量約1450を算出した.又S-DNase Iによる分解産物中のモノヌクレオチドが5'-燐酸であるという前報(1)の観察結果を, “Corn”分劃の末端燐酸基の結合位置についても,はぶ毒消化の結果やホスホモノエステラーゼ前処理によるホスホジエステラーゼ感受性の低下から敷衍する事が出来た.欺くてS-DNase ...
openaire +3 more sources
Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance
Signal Transduction and Targeted TherapyAnemia is one of the most prevalent systemic complications in patients with cancer, substantially impairing quality of life and limiting the safe administration of cytoreductive therapies. Despite its clinical significance, the mechanisms by which tumors
Ting Yuan +23 more
doaj +1 more source
Deoxyribonuclease I Activity, Cell-Free DNA, and Risk of Liver Cancer in a Prospective Cohort. [PDF]
JNCI Cancer Spectr, 2018 Golonka RM +7 more
europepmc +1 more source
Effect of deoxyribonuclease I treatment for dementia in end-stage Alzheimer's disease: a case report. [PDF]
J Med Case Rep, 2016 Tetz V, Tetz G.
europepmc +1 more source
Ultrasensitive fluorescent aptasensor for MUC1 detection based on deoxyribonuclease I-aided target recycling signal amplification. [PDF]
RSC Adv, 2018 Zhang J +8 more
europepmc +1 more source