High Nucleosome Occupancy Is Encoded at Human Regulatory Sequences [PDF]
, 2009 Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters,
Andrea J. Gossett +10 more
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Effect of deoxyribonuclease-deficiency on myeloid cells under homeostatic and inflammatory conditions [PDF]
, 2022 In healthy and diseased individuals, endogenous nucleic acids are present in various forms and need to be processed and cleared. Failed clearance of DNA is associated with an autoimmune disease termed systemic lupus erythematosus (SLE), which is ...
Reuter, Tatjana
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Restriction-modification system with methyl-inhibited base excision and abasic-site cleavage activities [PDF]
, 2015 The restriction-modification systems use epigenetic modification to distinguish between self and nonself DNA. A modification enzyme transfers a methyl group to a base in a specific DNA sequence while its cognate restriction enzyme introduces breaks in ...
Fukuyo, Masaki +9 more
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Discovery of a novel restriction endonuclease by genome comparison and application of a wheat-germ-based cell-free translation assay: PabI (5′-GTA/C) from the hyperthermophilic archaeon Pyrococcus abyssi [PDF]
, 2005 To search for restriction endonucleases, we used a novel plant-based cell-free translation procedure that bypasses the toxicity of these enzymes. To identify candidate genes, the related genomes of the hyperthermophilic archaea Pyrococcus abyssi and ...
Bujnicki, Janusz M. +7 more
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The Enzymology and Genetics of Dna Repair in Drosophila Melanogaster (Ap Endonucleases, Oregon-R, Mus(2)201, Cleavage Mechanisms). [PDF]
, 1985 The work presented herein investigates the repair of apurinic/apyrimidinic (AP) sites in Drosophila melanogaster. Two different AP endonucleases were isolated differing in pH optima, reaction requirements, and associated activities.
Spiering, Andrea Lynn
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What did CRISPR-Cas9 accomplish in its first 10 years? [PDF]
, 2023 It’s been 10 years now from the debut of clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR/Cas9) era in which gene engineering has never been so accessible, precise and efficient.
Khlidj, Yehya
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Mesoporous Silica-Based Supports for the Controlled and Targeted Release of Bioactive Molecules in the Gastrointestinal Tract [PDF]
, 2015 JFS Special Issue: 75 Years of Advancing Food Science, and Preparing for the Next 75Mesoporous silica particles (MSPs) have attracted increasing interest as supports in the design of controlled delivery materials.
Barat Baviera, José Manuel +3 more
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Red light delays programmed cell death in non-host interaction between Pseudomonas syringae pv tomato DC3000 and tobacco plants [PDF]
, 2020 Light modulates almost every aspect of plant physiology, including plant-pathogen interactions. Among these, the hypersensitive response (HR) of plants to pathogens is characterized by a rapid and localized programmed cell death (PCD), which is critical ...
Carrau, Analía +6 more
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Success of a suicidal defense strategy against infection in a structured habitat [PDF]
, 2012 Pathogen infection often leads to the expression of virulence and host death when the host-pathogen symbiosis seems more beneficial for the pathogen. Previously proposed explanations have focused on the pathogen's side.
A Mochizuki +20 more
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A Genetic and Developmental Analysis of a Soluble Acid Deoxyribonuclease in Drosophila melanogaster [PDF]
, 1978 A deoxyribonuclease, called DNase-1, that is active at acid pH in the presence of EDTA has been studied in Drosophila melanogaster. The locus for the enzyme maps genetically to 61.8 on the right arm of the third chromosome.
Detwiler, Charles, MacIntyre, Ross
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