Results 11 to 20 of about 16,138 (134)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

CRISPR DNA elements controlling site-specific spacer integration and proper repeat length by a Type II CRISPR–Cas system

Nucleic Acids Research, 2019
CRISPR–Cas systems provide heritable immunity against viruses by capturing short invader DNA sequences, termed spacers, and incorporating them into the CRISPR loci of the prokaryotic host genome.
J. Kim, Sandra C. Garrett, Yunzhou Wei, B. Graveley, M. Terns   +4 more
semanticscholar   +1 more source

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry

Nucleic Acids Research, 2017
Human type II topoisomerase (Top2) isoforms, hTop2α and hTop2β, are targeted by some of the most successful anticancer drugs. These drugs induce Top2-mediated DNA cleavage to trigger cell-death pathways.
Ying-Ren Wang, Shin-Fu Chen, Chyuan-Chuan Wu, Yi‐Wen Liao, Te-Sheng Lin, Ko-Ting Liu, Yi-Song Chen, Tsai-Kun Li, Tun-Cheng Chien, N. Chan   +9 more
semanticscholar   +1 more source

The Potential Active Site of the Lipoprotein-specific (Type II) Signal Peptidase of Bacillus subtilis *

Journal of Biological Chemistry, 1999
Type II signal peptidases (SPase II) remove signal peptides from lipid-modified preproteins of eubacteria. As the catalytic mechanism employed by type II SPases was not known, the present studies were aimed at the identification of their potential active
H. Tjalsma, Geeske Zanen, G. Venemâ, S. Bron, J. V. van Dijl   +4 more
semanticscholar   +1 more source

Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2)

Molecules, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused about 2 million infections and is responsible for more than 100,000 deaths worldwide. To date, there is no specific drug registered to combat the disease it causes, named coronavirus
Noor Rahman, Zarrin Basharat, M. Yousuf, G. Castaldo, L. Rastrelli, H. Khan   +5 more
semanticscholar   +1 more source

The coiled coil of in vitro assembled keratin filaments is a heterodimer of type I and II keratins: use of site-specific mutagenesis and recombinant protein expression

Journal of Cell Biology, 1990
Recombinant DNA technology has been used to analyze the first step in keratin intermediate filament (IF) assembly; i.e., the formation of the double stranded coiled coil.
M. Hatzfeld, K. Weber
semanticscholar   +1 more source

Plasma Proteins Modified by Advanced Glycation End Products (AGEs) Reveal Site-specific Susceptibilities to Glycemic Control in Patients with Type 2 Diabetes*

Journal of Biological Chemistry, 2016
Protein glycation refers to the reversible reaction between aldoses (or ketoses) and amino groups yielding relatively stable Amadori (or Heyns) products.
Uta Greifenhagen, A. Frolov, M. Blüher, R. Hoffmann   +3 more
semanticscholar   +1 more source

Intense interval training in healthy older adults increases skeletal muscle [3H]ouabain‐binding site content and elevates Na+,K+‐ATPase α2 isoform abundance in Type II fibers

Physiological Reports, 2017
Young adults typically adapt to intense exercise training with an increased skeletal muscle Na+,K+‐ATPase (NKA) content, concomitant with reduced extracellular potassium concentration [K+] during exercise and enhanced exercise performance.
V. Wyckelsma, I. Levinger, R. Murphy, A. Petersen, B. Perry, C. Hedges, Mitchell J. Anderson, M. McKenna   +7 more
semanticscholar   +1 more source

Definition of the Native and Denatured Type II Collagen Binding Site for Fibronectin Using a Recombinant Collagen System*

Journal of Biological Chemistry, 2013
Background: Sequence requirements for triple-helical collagen to bind fibronectin are not fully understood. Results: Fibronectin affinity was conferred on a recombinant bacterial collagen by incorporating specific human collagen II sequences. Conclusion:
B. An, V. Abbonante, Sezin Yigit, A. Balduini, D. Kaplan, B. Brodsky   +5 more
semanticscholar   +1 more source

Global site-specific analysis of glycoprotein N-glycan processing

Nature Protocols, 2018
N-glycans contribute to the folding, stability and functions of the proteins they decorate. They are produced by transfer of the glycan precursor to the sequon Asn-X-Thr/Ser, followed by enzymatic trimming to a high-mannose-type core and sequential ...
Liwei Cao, J. Diedrich, Yuanhui Ma, Nianshuang Wang, M. Pauthner, S. Park, C. Delahunty, J. McLellan, D. Burton, J. Yates, J. Paulson   +10 more
semanticscholar   +1 more source