Effect of deoxyribonuclease-deficiency on myeloid cells under homeostatic and inflammatory conditions [PDF]
, 2022 In healthy and diseased individuals, endogenous nucleic acids are present in various forms and need to be processed and cleared. Failed clearance of DNA is associated with an autoimmune disease termed systemic lupus erythematosus (SLE), which is ...
Reuter, Tatjana
core +1 more source
High Nucleosome Occupancy Is Encoded at Human Regulatory Sequences [PDF]
, 2009 Active eukaryotic regulatory sites are characterized by open chromatin, and yeast promoters and transcription factor binding sites (TFBSs) typically have low intrinsic nucleosome occupancy. Here, we show that in contrast to yeast, DNA at human promoters,
Andrea J. Gossett +10 more
core +16 more sources
Expert Review of Gastroenterology & Hepatology, 2020 Background The effect of distant metastasis on prognosis in patients with Siewert type II adenocarcinoma of the esophagogastric junction (AEG) remains elusive.
Kun Chen +8 more
semanticscholar +1 more source
Construction of extremal Type II $\mathbb{Z}_{2k}$-codes [PDF]
, 2022 We give methods for constructing many self-dual $\mathbb{Z}_m$-codes and Type II $\mathbb{Z}_{2k}$-codes of length $2n$ starting from a given self-dual $\mathbb{Z}_m$-code and Type II $\mathbb{Z}_{2k}$-code of length $2n$, respectively. As an application, we construct extremal Type II $\mathbb{Z}_{2k}$-codes of length $24$ for $k=4,5,\ldots,20$ and ...
arxiv +1 more source
Nucleic Acids Research, 2019 CRISPR–Cas systems provide heritable immunity against viruses by capturing short invader DNA sequences, termed spacers, and incorporating them into the CRISPR loci of the prokaryotic host genome.
J. Kim +4 more
semanticscholar +1 more source
The Enzymology and Genetics of Dna Repair in Drosophila Melanogaster (Ap Endonucleases, Oregon-R, Mus(2)201, Cleavage Mechanisms). [PDF]
, 1985 The work presented herein investigates the repair of apurinic/apyrimidinic (AP) sites in Drosophila melanogaster. Two different AP endonucleases were isolated differing in pH optima, reaction requirements, and associated activities.
Spiering, Andrea Lynn
core +2 more sources
A Comparative Study of Long and Short GRBs. II. A Multi-wavelength Method to distinguish Type II (massive star) and Type I (compact star) GRBs [PDF]
, 2020 Gamma Ray Burst (GRBs) are empirically classified as long-duration GRBs (LGRBs, $>$ 2s) and short-duration GRBs (SGRBs, $<$ 2s). Physically they can be grouped into two distinct progenitor categories: those originating from collapse of massive stars (also known as Type II) and those related to mergers of compact stars (also known as Type I).
arxiv +1 more source
Nucleic Acids Research, 2017 Human type II topoisomerase (Top2) isoforms, hTop2α and hTop2β, are targeted by some of the most successful anticancer drugs. These drugs induce Top2-mediated DNA cleavage to trigger cell-death pathways.
Ying-Ren Wang +9 more
semanticscholar +1 more source
Discovery of a novel restriction endonuclease by genome comparison and application of a wheat-germ-based cell-free translation assay: PabI (5′-GTA/C) from the hyperthermophilic archaeon Pyrococcus abyssi [PDF]
, 2005 To search for restriction endonucleases, we used a novel plant-based cell-free translation procedure that bypasses the toxicity of these enzymes. To identify candidate genes, the related genomes of the hyperthermophilic archaea Pyrococcus abyssi and ...
Bujnicki, Janusz M. +7 more
core +2 more sources
The Translocating RecBCD Enzyme Stimulates Recombination by Directing RecA Protein onto ssDNA in a χ-Regulated Manner [PDF]
, 1997 Double-stranded DNA break repair and homologous recombination in E. coli are initiated by the RecBCD enzyme, which unwinds and simultaneously degrades DNA from a double-stranded DNA end.
Anderson, Daniel G +1 more
core +1 more source