Results 21 to 30 of about 4,358 (132)

Matrix attachment regions as targets for retroviral integration [PDF]

, 2005
BACKGROUND: The randomness of retroviral integration has been debated for many years. Recent evidence indicates that integration site selection is not random, and that it is influenced by both viral and cellular factors.
Johnson, Chassidy N, Levy, Laura S
core   +3 more sources

Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer

Advanced Science, EarlyView.
An integrative analysis combining in vitro genome‐wide immune screens, in vivo ICB screens, and clinical data mining identifies METTL5 as a key tumor‐intrinsic immune factor. Mechanistic studies further reveal the importance of the METTL5‐ATF4‐SLC7A11/SLC3A2‐ferroptosis axis in modulating antitumor immune responses. These findings highlight METTL5 as a
Jiakai Hou, Cheng‐Wei Ju, Nicholas A. Egan, Yanjun Wei, Yunfei Wang, Minghao Dang, Tianyi Zhou, Leilei Shi, Ningbo Zheng, Si Chen, Ashley M. Guerrero, Xiaofang Liang, Wanfu Wu, Areej Akhtar, Chitra Dhiman, Debanwita Roy Burman, Andro E. Gerges, Mason D. Flores, Han Li, Li‐Sheng Zhang, Marleen Kok, Xiaobo Mao, Linghua Wang, Qin Feng, Yiwen Chen, Sanghoon Lee, Daniel J. McGrail, Nidhi Sahni, Chuan He, Amir A. Jazaeri, Weiyi Peng   +30 more
wiley   +1 more source

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, EarlyView.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

Activation of nucleases, pcd, and mobilization of reserves in the araucaria angustifolia megagametophyte during germination [PDF]

, 2018
The megagametophyte of mature seeds of Araucaria angustifolia consists of cells with thin walls, one or more nuclei, a central vacuole storing proteins, and a cytoplasm rich in amyloplasts, mitochondria and lipid bodies.
Correa, María D., Favre, Leonardo Cristian, Lopez Fernandez, Maria Paula, Maldonado, Sara Beatriz, Moyano, Laura, Rodríguez, Florencia S.   +5 more
core   +3 more sources

Nanoparticle‐Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy

Advanced Science, EarlyView.
This study presents a nanoparticle‐embedded nanofiber (5F/STFM/R‐ES) to inhibit melanoma growth and reduce the risk of metastasis and recurrence. The drug delivery system induces ferroptosis and potentiates immunotherapy through resiquimod (R848) and Fe/Mn‐based metal‐polyphenol networks (TFM).
Mingyang Li, Rongrong Li, Baotong Xu, Yuhan Lian, Chenyu Yang, Jingwen Li, Junhao Liang, Linhan Ding, Dongsheng Zhang, Jing Guo, Xiao Fu   +10 more
wiley   +1 more source

Hyaluronic Acid Hydrogel Implants for Sustained Release of Oxaliplatin and Resiquimod to Prevent Hepatocellular Carcinoma Recurrence Post‐Radiofrequency Ablation

Advanced Science, EarlyView.
Preparation of a biopolymer‐based immune implant (BI) for the sustained release of R848 and oxaliplatin (OXA), enabling immune activation and preventing recurrence after radiofrequency ablation (RFA) treatment in hepatocellular carcinoma (HCC). Abstract Hepatocellular carcinoma (HCC) remains a global challenge due to limited therapies and high ...
Yuezhan Shan, Hongyu Chu, Sheyu Ye, Guofeng Ji, Jiayi Zhao, Xinghui Si, Yumin Zhong, Youmao Tao, Jingwei Shi, Xuedong Fang   +9 more
wiley   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

Advanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian, Yonghong Xiong, Junbiao Zhan, Zhikun Lu, Yuxi Zhang, Yan Leng, Qin Huang, Zhongyuan Xia   +7 more
wiley   +1 more source

Mild Photothermal Bimetallic Mesoporous Nanozyme Triggers Immunogenic Cell Death and Immune Contexture Remodeling for Precision Hepatocellular Carcinoma Treatment

Advanced Science, EarlyView.
In this study, a Pt/Co BNzyme with peroxidase/GPx‐like activity is developed, increasing oxidative stress by generating ROS and depleting GSH to induce ICD. The mild PTT effect enhanced its enzymatic activity. The Pt/Co BNzyme remodeled the TME, promoting DC maturation.
Yanbing Huang, Lei Ding, Yanbing Cao, Qiang Feng, Yanjuan Li, Jianmin Wang, Zhixiong Cai, Fuli Xin, Peiyuan Wang, Jingfeng Liu   +9 more
wiley   +1 more source

A novel single-stranded DNA-specific 3′–5′ exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways [PDF]

Single-stranded DNA (ssDNA)-specific exonucleases (ssExos) are expected to be involved in a variety of DNA repair pathways corresponding to their cleavage polarities; however, the relationship between the cleavage polarity and the respective DNA repair ...
Agari, Akagawa, Atsuhiro Shimada, Back, Bernad, Bonura, Bourre, Bradley, Breyer, Burdett, Busam, Courcelle, Cromie, Crow, Dalhus, de Silva, de Silva, Dillingham, Franklin, Friedberg, Fukuda, Fukui, Fukui, Fukui, Han, Hashimoto, Hoseki, Ishii, Ivancic-Bace, Kadyrov, Kadyrov, Kenji Fukui, Kondo, Kunkel, Kwang Kim, Lee-Kirsch, Lehman, Lehman, Lombardo, Luria, McLuckey, Melancon, Michaels, Moazed, Modrich, Moe, Moe, Morelle, Morita, Moser, Noriko Nakagawa, Obmolova, Ooga, Perrino, Perrino, Piersen, Rosenstein, Ryoji Masui, Salzano, Sandigursky, Sandigursky, Sandigursky, Seeberg, Seiki Kuramitsu, Sharma, Shinkai, Sorek, Tachiki, Truglio, Viswanathan, Viswanathan, Waters, Weinfeld, Weiss, Weiss, Yamagata, Yokoyama, Yoshio Takahata, Zhang   +78 more
core   +2 more sources

Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates [PDF]

, 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Campbell, L, Jenner, R, von Reumont, B
core   +2 more sources