Results 21 to 30 of about 4,381 (132)

Development And Evaluation Of Terbutaline Sulphate Loaded-Biodegradable Microspheres For Pulmonary Delivery [PDF]

, 2007
Mikrosfera terbutalin sulfat (TBS) pelepasan tertahan dibangun menggunakan polimer PLA R 203H dan PLGA RG 504H. Sustained-release terbutaline sulphate (TBS) microspheres were developed using PLA R 203H and PLGA RG 504H ...
Mohammed Ahmed, Rehab Abdallah
core  

Matrix attachment regions as targets for retroviral integration [PDF]

, 2005
BACKGROUND: The randomness of retroviral integration has been debated for many years. Recent evidence indicates that integration site selection is not random, and that it is influenced by both viral and cellular factors.
Johnson, Chassidy N, Levy, Laura S
core   +3 more sources

Roles of Alp and Prt Regulons in the Response of Pseudomonas aeruginosa to UV‐C Light

Environmental Microbiology Reports, Volume 18, Issue 1, February 2026.
Our results show that LexA‐regulated genes are the first to be induced after DNA damage, while autolysis functions controlled by the Alp system are the last. Death by UV is mediated primarily by Alp or Prt systems, depending on the Pseudomonas aeruginosa subline. ABSTRACT UV light is a well‐studied environmental DNA damaging agent.
Marina R. B. Fonseca, Renatta S. Oliveira, Henrique Kustor, Rubia R. L. Freitas, Enzo B. S. Mello, Cristina E. Alvarez‐Martinez, Rodrigo S. Galhardo   +6 more
wiley   +1 more source

Activation of nucleases, pcd, and mobilization of reserves in the araucaria angustifolia megagametophyte during germination [PDF]

, 2018
The megagametophyte of mature seeds of Araucaria angustifolia consists of cells with thin walls, one or more nuclei, a central vacuole storing proteins, and a cytoplasm rich in amyloplasts, mitochondria and lipid bodies.
Correa, María D., Favre, Leonardo Cristian, Lopez Fernandez, Maria Paula, Maldonado, Sara Beatriz, Moyano, Laura, Rodríguez, Florencia S.   +5 more
core   +3 more sources

Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK‐ULK1‐Mediated Mitochondrial Quality Control

Aging Cell, Volume 25, Issue 2, February 2026.
Dietary protein restriction protects the aging heart in the context of obesity by limiting mitochondrial DNA leakage and suppressing cGAS–STING‐driven inflammation. Through AMPK–ULK1‐dependent mitophagy, protein restriction restores mitochondrial quality control, reduces cardiac remodeling, and preserves metabolic homeostasis during obesity‐associated ...
Wagner S. Dantas, Elizabeth R. M. Zunica, Elizabeth C. Heintz, Charles L. Hoppel, Cristal M. Hill, Christopher D. Morrison, Christopher L. Axelrod, Gangarao Davuluri, John P. Kirwan   +8 more
wiley   +1 more source

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration

Advanced Healthcare Materials, Volume 15, Issue 3, 19 January 2026.
Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan   +9 more
wiley   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, Volume 13, Issue 2, 9 January 2026.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

A novel single-stranded DNA-specific 3′–5′ exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways [PDF]

Single-stranded DNA (ssDNA)-specific exonucleases (ssExos) are expected to be involved in a variety of DNA repair pathways corresponding to their cleavage polarities; however, the relationship between the cleavage polarity and the respective DNA repair ...
Agari, Akagawa, Atsuhiro Shimada, Back, Bernad, Bonura, Bourre, Bradley, Breyer, Burdett, Busam, Courcelle, Cromie, Crow, Dalhus, de Silva, de Silva, Dillingham, Franklin, Friedberg, Fukuda, Fukui, Fukui, Fukui, Han, Hashimoto, Hoseki, Ishii, Ivancic-Bace, Kadyrov, Kadyrov, Kenji Fukui, Kondo, Kunkel, Kwang Kim, Lee-Kirsch, Lehman, Lehman, Lombardo, Luria, McLuckey, Melancon, Michaels, Moazed, Modrich, Moe, Moe, Morelle, Morita, Moser, Noriko Nakagawa, Obmolova, Ooga, Perrino, Perrino, Piersen, Rosenstein, Ryoji Masui, Salzano, Sandigursky, Sandigursky, Sandigursky, Seeberg, Seiki Kuramitsu, Sharma, Shinkai, Sorek, Tachiki, Truglio, Viswanathan, Viswanathan, Waters, Weinfeld, Weiss, Weiss, Yamagata, Yokoyama, Yoshio Takahata, Zhang   +78 more
core   +2 more sources

Nanoparticle‐Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy

Advanced Science, Volume 13, Issue 1, 5 January 2026.
This study presents a nanoparticle‐embedded nanofiber (5F/STFM/R‐ES) to inhibit melanoma growth and reduce the risk of metastasis and recurrence. The drug delivery system induces ferroptosis and potentiates immunotherapy through resiquimod (R848) and Fe/Mn‐based metal‐polyphenol networks (TFM).
Mingyang Li, Rongrong Li, Baotong Xu, Yuhan Lian, Chenyu Yang, Jingwen Li, Junhao Liang, Linhan Ding, Dongsheng Zhang, Jing Guo, Xiao Fu   +10 more
wiley   +1 more source