Results 91 to 100 of about 670,645 (305)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Dependency-based Compositional Synthesis
, 2020 Despite many recent advances, reactive synthesis is still not really a practical technique. The grand challenge is to scale from small transition systems, where synthesis performs well, to complex multi-component designs.
Bernd Finkbeiner (17288470) +1 more
core +1 more source
Comparative analysis of assistive technologies for Older People: Hoist or patients lifts
International Journal of Integrated Care, 2019 The use of mechanical lifting devices to mobilize reduced mobility people is installed in the context of integrated care systems and also it becomes and strategy for responding to an aging workforce.
Miguel Joaquín Tellaeche Reparaz +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Case Reports in Critical CareGuillain–Barré syndrome (GBS) is a major cause of neuromuscular respiratory failure globally. In many low-income settings, access to mechanical ventilation and disease-modifying therapy is limited. We describe the management of a young woman with rapidly
Lesley Notghi, Louise Little, Joel Chin
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Dependency and Social Inequality in Pre-Roman Italy [PDF]
In the past, most studies on Pre-Roman societies in Italy focused on the elites. The aim of this volume is to look at dependent and marginalized social groups, which are less visible and often even difficult to define.
core +1 more source
Journal of MultiDisciplinary Evaluation, 2018 Background & Purpose: This article summarizes and adds to the tools and infrastructure that the author has developed to hold donors and NGOs in international development to their own international, legal and professional standards, following a ...
David H. Lempert
doaj +1 more source