Results 71 to 80 of about 670,645 (305)

A flexible module-based cognitive behavioral therapy for gaming disorder: study protocol of a randomized controlled trial

Trials
Background Knowledge about gaming disorder has increased in recent years. However, more research is needed regarding treatment options for gaming disorder. The most studied treatment option today is cognitive behavioral therapy (CBT). However, due to the
Elin Arvidson, Annika Hofstedt, Anna Söderpalm Gordh   +2 more
doaj   +1 more source

Inclusion dependencies and their interaction with functional dependencies

Proceedings of the 1st ACM SIGACT-SIGMOD symposium on Principles of database systems - PODS '82, 1982
Inclusion dependencies, or INDs (which can say, for example, that every manager is an employee) are studied, including their interaction with functional dependencies, or FDs. A simple complete axiomatization for INDs is presented, and the decision problem for INDs is shown to be PSPACE-complete.
Marco A. Casanova, Ronald Fagin, Christos H. Papadimitriou   +2 more
openaire   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The efficacy of iCBT added to treatment as usual for alcohol-dependent patients in primary care: study protocol for a randomized controlled trial

Trials, 2019
Background Alcohol dependence is a common disorder with a continuum regarding severity. Most alcohol-dependent persons have a moderate level of dependence and live under socially orderly conditions.
Karin Hyland, Anders Hammarberg, Erik Hedman-Lagerlöf, Magnus Johansson, Sven Andreasson   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

El “afro” de don Fernando Ortiz y los “africanos” de Humboldt. “Afro”, “África”, Afro-Latinidad en la historia, memoria y herencia cultural de la América ibérica y el Caribe

HiN - Alexander von Humboldt im Netz. Internationale Zeitschrift für Humboldt-Studien
Este artículo examina la denominación de grandes grupos poblacionales en América, como los antiguos esclavos y sus descendientes. El grupo que hoy define el discurso sobre la esclavitud y sus consecuencias suele ser denominado “afros”.
Michael Zeuske
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Independency in the volumes of eggs of the Heerman's gull (Larus heermanni), on base to their clutching sequence

Ciencias Marinas, 2002
In most birds egg volume has been recorded directly dependant on clutch sequence. Furthermore, the egg size has been also considered as dependent on the size of its predecessor, thus, they are constantly analyzed with non-parametric statistics, given ...
R Carmona, E Lozano
doaj   +1 more source