Results 61 to 70 of about 87,543 (295)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Dependency theory and economic growth

open access: yes, 2012
This thesis examines the concept of dependency theory between developing and developed countries. Formerly popular concept explains reasons of underdevelopment in poor countries. This work discusses about two main approaches as the structuralism and neo-
Béreš, Adam
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Liberation and dependency: a theological reading of social sciences in Latin America

open access: yesMissionalia: Southern African Journal of Missiology, 2015
Introduction: In the early 1970s, social movements directed Latin American theologyto a creative process of deprivatization of the Christian faith, reconfiguring fromthe community practices of liberation and their holistic implications the ...
Teixeira, Helio Aparecido Campos   +1 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Nobody Notices It? Qualitative Inequalities of Leading Publications in Communication and Media Research

open access: yesInternational Journal of Communication, 2018
This article examines the publication practices in the field of communication and media studies (CMS) by analyzing the main patterns and features of Scopus-indexed journals.
Marton Demeter
doaj  

Diffusion of Innovation vs. Dependence Theory: FinTech Inclusion in the AfCFTA Era

open access: yesJournal of Financial and Management Sciences
The African Continental Free Trade Area (AfCFTA) aspires to accelerate digital financial integration across Africa, yet the diffusion of FinTech innovations shows uneven patterns shaped by deep-seated power structures.
Sixbert SANGWA   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy