Results 1 to 10 of about 6,580 (108)

Novel Parvoviruses from Wild and Domestic Animals in Brazil Provide New Insights into Parvovirus Distribution and Diversity [PDF]

Viruses, 2018
Parvoviruses (family Parvoviridae) are small, single-stranded DNA viruses. Many parvoviral pathogens of medical, veterinary and ecological importance have been identified.
William Marciel de Souza, Tristan Dennis, Marcílio Jorge Fumagalli, Jansen Araujo, Gilberto Sabino-Santos, Felipe Gonçalves Motta Maia, Gustavo Olszanski Acrani, Adriano de Oliveira Torres Carrasco, Marilia Farignoli Romeiro, Sejal Modha, Luiz Carlos Vieira, Tatiana Ometto, Luzia Helena Queiroz, Edison Luiz Durigon, Márcio Roberto Teixeira Nunes, Luiz Tadeu Moraes Figueiredo, Robert James Gifford   +16 more
doaj   +5 more sources

A sensitive and reproducible cell-based assay via secNanoLuc to detect neutralizing antibody against adeno-associated virus vector capsid

Molecular Therapy: Methods & Clinical Development, 2021
Most gene therapy clinical trials that systemically administered adeno-associated virus (AAV) vector enrolled only patients without anti-AAV-neutralizing antibodies.
Nemekhbayar Baatartsogt, Yuji Kashiwakura, Morisada Hayakawa, Nobuhiko Kamoshita, Takafumi Hiramoto, Hiroaki Mizukami, Tsukasa Ohmori   +6 more
doaj   +1 more source

The seroprevalence of neutralizing antibodies against the adeno-associated virus capsids in Japanese hemophiliacs

Molecular Therapy: Methods & Clinical Development, 2022
Adeno-associated virus (AAV) vectors are promising modalities of gene therapy to address unmet medical needs. However, anti-AAV neutralizing antibodies (NAbs) hamper the vector-mediated therapeutic effect.
Yuji Kashiwakura, Nemekhbayar Baatartsogt, Shoji Yamazaki, Azusa Nagao, Kagehiro Amano, Nobuaki Suzuki, Tadashi Matsushita, Akihiro Sawada, Satoshi Higasa, Naoya Yamasaki, Teruhisa Fujii, Taemi Ogura, Hideyuki Takedani, Masashi Taki, Takeshi Matsumoto, Jun Yamanouchi, Michio Sakai, Masako Nishikawa, Yutaka Yatomi, Koji Yada, Keiji Nogami, Ryota Watano, Takafumi Hiramoto, Morisada Hayakawa, Nobuhiko Kamoshita, Akihiro Kume, Hiroaki Mizukami, Shizukiyo Ishikawa, Yoichi Sakata, Tsukasa Ohmori   +29 more
doaj   +1 more source

Astrovirus Outbreak in an Animal Shelter Associated With Feline Vomiting

Frontiers in Veterinary Science, 2021
An outbreak of cat vomiting was observed in an animal shelter. Testing for known enteric feline pathogens did not identify a causative agent. Viral metagenomics on four mini pools of feces from cases and controls housed in the same area revealed the ...
Yanpeng Li, Yanpeng Li, Emilia Gordon, Amanda Idle, Alvin Hui, Roxanne Chan, M. Alexis Seguin, Eric Delwart, Eric Delwart   +8 more
doaj   +1 more source

Gene therapy in neuromuscular disorders

Arquivos de Neuro-Psiquiatria, 2022
Monogenic neuromuscular disorders are potentially treatable through gene therapy. Using viral vectors, a therapeutic transgene aims to restore normal levels of a protein not produced by the defective gene, or to silence a gene whose expression leads to ...
Rodrigo Holanda Mendonça, Edmar Zanoteli   +1 more
doaj   +1 more source

Functional roles of the membrane-associated AAV protein MAAP

Scientific Reports, 2021
With a limited coding capacity of 4.7 kb, adeno-associated virus (AAV) genome has evolved over-lapping genes to maximise the usage of its genome. An example is the recently found ORF in the cap gene, encoding membrane-associated accessory protein (MAAP),
Lionel Galibert, Amira Hyvönen, Reetta A. E. Eriksson, Salla Mattola, Vesa Aho, Sami Salminen, Justin D. Albers, Sanna K. Peltola, Saija Weman, Tiina Nieminen, Seppo Ylä-Herttuala, Hanna P. Lesch, Maija Vihinen-Ranta, Kari J. Airenne   +13 more
doaj   +1 more source

Novel Mutant AAV2 Rep Proteins Support AAV2 Replication without Blocking HSV-1 Helpervirus Replication. [PDF]

PLoS ONE, 2017
As their names imply, parvoviruses of the genus Dependovirus rely for their efficient replication on the concurrent presence of a helpervirus, such as herpesvirus, adenovirus, or papilloma virus.
Michael Seyffert, Daniel L Glauser, Elisabeth M Schraner, Anna-Paula de Oliveira, Jorge Mansilla-Soto, Bernd Vogt, Hildegard Büning, R Michael Linden, Mathias Ackermann, Cornel Fraefel   +9 more
doaj   +1 more source

Non‐A to E hepatitis in children: Detecting a novel viral epidemic during the COVID‐19 pandemic

Microbial Biotechnology, 2023
During the COVID‐19 pandemic, two further novel viral epidemics were described in 2022, monkeypox virus infections in men having sex with men and non‐A to E hepatitis in children.
Harald Brüssow
doaj   +1 more source

Construcción de un vector de expresión derivado de virus adenoasociados para corregir in vitro el defecto genético de la enfermedad de Morquio A

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. La mucopolisacaridosis IV A (Morquio A) es una enfermedad de depósito lisosómico causada por la deficiencia en la actividad de la enzima N-acetil-galactosamina- 6-sulfato-sulfatasa que produce la acumulación intralisosómica de queratán y ...
Luis Alejandro Barrera, Mónica A. Gutiérrez, Felipe García Vallejo, Shunji Tomatsu, Flavio Cerón, Carlos J. Alméciga Díaz, Martha C. Domínguez   +6 more
doaj   +1 more source

Parvovirus-derived endogenous viral elements in two South American rodent genomes [PDF]

, 2014
We describe endogenous viral elements (EVEs) derived from parvoviruses (family <i>Parvoviridae</i>) in the long-tailed chinchilla (<i>Chinchilla lanigera</i>) and degu (<i>Octodon degus</i>) genomes.
Abascal, Antoine, Ardiles, Arnaud, Belyi, Bezier, Dewannieux, G. Arriagada, Gould, Guindon, Kapoor, Katzourakis, Kumar, Liu, Naccache, Okanoya, Opazo, Phan, R. J. Gifford, Rowe, Smuts   +20 more
core   +1 more source