Results 21 to 30 of about 6,342 (125)
Medicinal Research Reviews, Volume 43, Issue 4, Page 829-854, July 2023., 2023 Abstract Despite the devastating clinical outcome of the neurodegenerative disease, amyotrophic lateral sclerosis (ALS), its etiology remains mysterious. Approximately 90% of ALS is characterized as sporadic, signifying that the patient has no family history of the disease.
Jessica Merjane +3 more
wiley +1 more source
Gene therapy in neuromuscular disorders
Arquivos de Neuro-Psiquiatria, 2022 Monogenic neuromuscular disorders are potentially treatable through gene therapy. Using viral vectors, a therapeutic transgene aims to restore normal levels of a protein not produced by the defective gene, or to silence a gene whose expression leads to ...
Rodrigo Holanda Mendonça +1 more
doaj +1 more source
The Analysis of Oral and Fecal Virome Detects Multiple Novel Emerging Viruses in Snakes
Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023 Wild animals are considered reservoirs for emerging and reemerging viruses, such as the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Previous studies have reported that bats and ticks harbored variable important pathogenic viruses, some of which could cause potential diseases in humans and livestock, while viruses carried by ...
Aijing Liu +13 more
wiley +1 more source
The Expression Strategy of Goose Parvovirus Exhibits Features of both the Dependovirus and Parvovirus Genera [PDF]
Journal of Virology, 2005 ABSTRACT The RNA transcription profile of the goose parvovirus (GPV) was determined, and it is a surprising hybrid of features of the Parvovirus and Dependovirus genera of the Parvovirinae subfamily of the Parvoviridae . Similar to the
Jianming, Qiu +4 more
openaire +2 more sources
Seroprevalence to adeno‐associated virus type 6 in people with hemophilia B from a UK adult cohort
Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 4, May 2022., 2022 Abstract Background Gene therapy shows promise as a potential “cure” for hemophilia A and B. Adeno‐associated virus (AAV) vectors are the leading platform to deliver modified genetic code of factor VIII or IX to the liver effecting endogenous production. Patient exposure to wild‐type AAV leads to the formation of neutralizing factors, which can prevent
Sara Boyce +9 more
wiley +1 more source
Biotechnology Journal, Volume 16, Issue 4, April 2021., 2021 This review focus on the advancements of the molecular design of baculovirus vectors for high yield production of adeno‐associated virus (AAV) vectors for gene delivery describing the different generation of expression vectors with associated advantages and critical limitations.
Pranav R.H. Joshi +3 more
wiley +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2008 Introducción. La mucopolisacaridosis IV A (Morquio A) es una enfermedad de depósito lisosómico causada por la deficiencia en la actividad de la enzima N-acetil-galactosamina- 6-sulfato-sulfatasa que produce la acumulación intralisosómica de queratán y ...
Luis Alejandro Barrera +6 more
doaj +1 more source
Detection and Genetic Analysis of Porcine Bocavirus in Different Swine Herds in North Central China
The Scientific World Journal, Volume 2014, Issue 1, 2014., 2014 Porcine Bocavirus (PBoV) has been reported to be associated with postweaning multisystemic wasting syndrome and pneumonia in pigs. In this study, a survey was conducted to evaluate the prevalence of PBoV in slaughter pigs, sick pigs, asymptomatic pigs and classical swine fever virus (CSFV) eradication plan herds in five provinces of China (Henan ...
Mengmeng Liu +7 more
wiley +1 more source
A Comparative Analysis of the Structural Architecture of ssDNA Viruses
Computational and Mathematical Methods in Medicine, Volume 9, Issue 34, Page 183-196, 2008., 2008 Virus assembly, utilizing a limited number of viral coat protein (CP or VP) building blocks, is an excellent example of a directed macromolecular interaction occurring in nature. Two basic principles govern the assembly of spherical (icosahedral) viruses: (i) Genetic Economy – the encapsidated genome encodes a single or few CPs that assemble a ...
Antonette Bennett +2 more
wiley +1 more source