Results 11 to 20 of about 6,474 (125)
Molecular Therapy: Methods & Clinical Development, 2022 Adeno-associated virus (AAV) vectors are promising modalities of gene therapy to address unmet medical needs. However, anti-AAV neutralizing antibodies (NAbs) hamper the vector-mediated therapeutic effect.
Yuji Kashiwakura +29 more
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Astrovirus Outbreak in an Animal Shelter Associated With Feline Vomiting
Frontiers in Veterinary Science, 2021 An outbreak of cat vomiting was observed in an animal shelter. Testing for known enteric feline pathogens did not identify a causative agent. Viral metagenomics on four mini pools of feces from cases and controls housed in the same area revealed the ...
Yanpeng Li +8 more
doaj +1 more source
Australian Veterinary Journal, Volume 101, Issue 9, Page 366-372, September 2023., 2023 Emerging diseases are acknowledged as a growing threat to wildlife, with the continued identification of pathogenic and potentially pathogenic viruses in avian species resulting from ongoing advances in molecular diagnostic techniques. Parvoviruses under the genus Chaphamaparvovirus (subfamily Hamaparvovirinae) are highly divergent.
M Sutherland, S Sarker
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 27, Issue 18, Page 2714-2729, September 2023., 2023 Abstract Recombinant adeno‐associated virus (rAAV) is an extremely attractive vector in the in vivo delivery of gene therapy as it is safe and its genome is simple. However, challenges including low permissiveness to specific cells and restricted tissue specificity have hindered its clinical application.
Xiaoping Huang +7 more
wiley +1 more source
Gene therapy in neuromuscular disorders
Arquivos de Neuro-Psiquiatria, 2022 Monogenic neuromuscular disorders are potentially treatable through gene therapy. Using viral vectors, a therapeutic transgene aims to restore normal levels of a protein not produced by the defective gene, or to silence a gene whose expression leads to ...
Rodrigo Holanda Mendonça +1 more
doaj +1 more source
Coinfection of a Bearded Dragon, Pogona vitticeps , with Adenovirus- and Dependovirus-like Viruses [PDF]
Veterinary Pathology, 1996 Four neonate bearded dragons, Pogona vitticeps, from two collections became ill and died. Multiple tissues were collected and processed for light microscopy. In hematoxylin and eosin-stained sections of liver of one lizard, numerous basophilic intranuclear inclusions were observed.
E R, Jacobson +3 more
openaire +2 more sources
Medicinal Research Reviews, Volume 43, Issue 4, Page 829-854, July 2023., 2023 Abstract Despite the devastating clinical outcome of the neurodegenerative disease, amyotrophic lateral sclerosis (ALS), its etiology remains mysterious. Approximately 90% of ALS is characterized as sporadic, signifying that the patient has no family history of the disease.
Jessica Merjane +3 more
wiley +1 more source
The Analysis of Oral and Fecal Virome Detects Multiple Novel Emerging Viruses in Snakes
Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023 Wild animals are considered reservoirs for emerging and reemerging viruses, such as the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Previous studies have reported that bats and ticks harbored variable important pathogenic viruses, some of which could cause potential diseases in humans and livestock, while viruses carried by ...
Aijing Liu +13 more
wiley +1 more source
The Expression Strategy of Goose Parvovirus Exhibits Features of both the Dependovirus and Parvovirus Genera [PDF]
Journal of Virology, 2005 ABSTRACT The RNA transcription profile of the goose parvovirus (GPV) was determined, and it is a surprising hybrid of features of the Parvovirus and Dependovirus genera of the Parvovirinae subfamily of the Parvoviridae . Similar to the
Jianming, Qiu +4 more
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Seroprevalence to adeno‐associated virus type 6 in people with hemophilia B from a UK adult cohort
Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 4, May 2022., 2022 Abstract Background Gene therapy shows promise as a potential “cure” for hemophilia A and B. Adeno‐associated virus (AAV) vectors are the leading platform to deliver modified genetic code of factor VIII or IX to the liver effecting endogenous production. Patient exposure to wild‐type AAV leads to the formation of neutralizing factors, which can prevent
Sara Boyce +9 more
wiley +1 more source