Results 11 to 20 of about 6,673 (141)

Non‐A to E hepatitis in children: Detecting a novel viral epidemic during the COVID‐19 pandemic

open access: yesMicrobial Biotechnology, 2023
During the COVID‐19 pandemic, two further novel viral epidemics were described in 2022, monkeypox virus infections in men having sex with men and non‐A to E hepatitis in children.
Harald Brüssow
doaj   +2 more sources

Novel Parvoviruses from Wild and Domestic Animals in Brazil Provide New Insights into Parvovirus Distribution and Diversity [PDF]

open access: yesViruses, 2018
Parvoviruses (family Parvoviridae) are small, single-stranded DNA viruses. Many parvoviral pathogens of medical, veterinary and ecological importance have been identified.
William Marciel de Souza   +16 more
doaj   +5 more sources

Liver virome of a Little Corella (Cacatua sanguinea) reveals coinfection with a novel parvovirus and two beak and feather disease viruses [PDF]

open access: yesAustralian Veterinary Journal, Volume 101, Issue 9, Page 366-372, September 2023., 2023
Emerging diseases are acknowledged as a growing threat to wildlife, with the continued identification of pathogenic and potentially pathogenic viruses in avian species resulting from ongoing advances in molecular diagnostic techniques. Parvoviruses under the genus Chaphamaparvovirus (subfamily Hamaparvovirinae) are highly divergent.
M Sutherland, S Sarker
wiley   +3 more sources

MiR133b‐mediated inhibition of EGFR‐PTK pathway promotes rAAV2 transduction by facilitating intracellular trafficking and augmenting second‐strand synthesis

open access: yesJournal of Cellular and Molecular Medicine, Volume 27, Issue 18, Page 2714-2729, September 2023., 2023
Abstract Recombinant adeno‐associated virus (rAAV) is an extremely attractive vector in the in vivo delivery of gene therapy as it is safe and its genome is simple. However, challenges including low permissiveness to specific cells and restricted tissue specificity have hindered its clinical application.
Xiaoping Huang   +7 more
wiley   +1 more source

Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno‐associated viral vectors

open access: yesMedicinal Research Reviews, Volume 43, Issue 4, Page 829-854, July 2023., 2023
Abstract Despite the devastating clinical outcome of the neurodegenerative disease, amyotrophic lateral sclerosis (ALS), its etiology remains mysterious. Approximately 90% of ALS is characterized as sporadic, signifying that the patient has no family history of the disease.
Jessica Merjane   +3 more
wiley   +1 more source

The Analysis of Oral and Fecal Virome Detects Multiple Novel Emerging Viruses in Snakes

open access: yesTransboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
Wild animals are considered reservoirs for emerging and reemerging viruses, such as the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Previous studies have reported that bats and ticks harbored variable important pathogenic viruses, some of which could cause potential diseases in humans and livestock, while viruses carried by ...
Aijing Liu   +13 more
wiley   +1 more source

Seroprevalence to adeno‐associated virus type 6 in people with hemophilia B from a UK adult cohort

open access: yesResearch and Practice in Thrombosis and Haemostasis, Volume 6, Issue 4, May 2022., 2022
Abstract Background Gene therapy shows promise as a potential “cure” for hemophilia A and B. Adeno‐associated virus (AAV) vectors are the leading platform to deliver modified genetic code of factor VIII or IX to the liver effecting endogenous production. Patient exposure to wild‐type AAV leads to the formation of neutralizing factors, which can prevent
Sara Boyce   +9 more
wiley   +1 more source

Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform

open access: yesBiotechnology Journal, Volume 16, Issue 4, April 2021., 2021
This review focus on the advancements of the molecular design of baculovirus vectors for high yield production of adeno‐associated virus (AAV) vectors for gene delivery describing the different generation of expression vectors with associated advantages and critical limitations.
Pranav R.H. Joshi   +3 more
wiley   +1 more source

Construcción de un vector de expresión derivado de virus adenoasociados para corregir in vitro el defecto genético de la enfermedad de Morquio A

open access: yesBiomédica: revista del Instituto Nacional de Salud, 2008
Introducción. La mucopolisacaridosis IV A (Morquio A) es una enfermedad de depósito lisosómico causada por la deficiencia en la actividad de la enzima N-acetil-galactosamina- 6-sulfato-sulfatasa que produce la acumulación intralisosómica de queratán y ...
Luis Alejandro Barrera   +6 more
doaj   +1 more source

Parvovirus-derived endogenous viral elements in two South American rodent genomes [PDF]

open access: yes, 2014
We describe endogenous viral elements (EVEs) derived from parvoviruses (family <i>Parvoviridae</i>) in the long-tailed chinchilla (<i>Chinchilla lanigera</i>) and degu (<i>Octodon degus</i>) genomes.
Abascal   +20 more
core   +1 more source

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