Results 11 to 20 of about 6,002 (83)

Astrovirus Outbreak in an Animal Shelter Associated With Feline Vomiting

Frontiers in Veterinary Science, 2021
An outbreak of cat vomiting was observed in an animal shelter. Testing for known enteric feline pathogens did not identify a causative agent. Viral metagenomics on four mini pools of feces from cases and controls housed in the same area revealed the ...
Yanpeng Li, Yanpeng Li, Emilia Gordon, Amanda Idle, Alvin Hui, Roxanne Chan, M. Alexis Seguin, Eric Delwart, Eric Delwart   +8 more
doaj   +1 more source

MiR133b‐mediated inhibition of EGFR‐PTK pathway promotes rAAV2 transduction by facilitating intracellular trafficking and augmenting second‐strand synthesis

Journal of Cellular and Molecular Medicine, Volume 27, Issue 18, Page 2714-2729, September 2023., 2023
Abstract Recombinant adeno‐associated virus (rAAV) is an extremely attractive vector in the in vivo delivery of gene therapy as it is safe and its genome is simple. However, challenges including low permissiveness to specific cells and restricted tissue specificity have hindered its clinical application.
Xiaoping Huang, Xiao Wang, Ling Li, Qizhao Wang, Wentao Xu, Wenlin Wu, Xiaolan Xie, Yong Diao   +7 more
wiley   +1 more source

Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno‐associated viral vectors

Medicinal Research Reviews, Volume 43, Issue 4, Page 829-854, July 2023., 2023
Abstract Despite the devastating clinical outcome of the neurodegenerative disease, amyotrophic lateral sclerosis (ALS), its etiology remains mysterious. Approximately 90% of ALS is characterized as sporadic, signifying that the patient has no family history of the disease.
Jessica Merjane, Roger Chung, Rickie Patani, Leszek Lisowski   +3 more
wiley   +1 more source

The Analysis of Oral and Fecal Virome Detects Multiple Novel Emerging Viruses in Snakes

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
Wild animals are considered reservoirs for emerging and reemerging viruses, such as the novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Previous studies have reported that bats and ticks harbored variable important pathogenic viruses, some of which could cause potential diseases in humans and livestock, while viruses carried by ...
Aijing Liu, Zhige Tian, Chuanming Yin, Jie Zou, Shan Wu, Yi Luo, Xin Chen, Yi Dai, Siyi Yang, Yanxi Li, Tongyu Li, Peng Guo, Xiaoliang Hu, Chunfu Zheng   +13 more
wiley   +1 more source

Gene therapy in neuromuscular disorders

Arquivos de Neuro-Psiquiatria, 2022
Monogenic neuromuscular disorders are potentially treatable through gene therapy. Using viral vectors, a therapeutic transgene aims to restore normal levels of a protein not produced by the defective gene, or to silence a gene whose expression leads to ...
Rodrigo Holanda Mendonça, Edmar Zanoteli   +1 more
doaj   +1 more source

Seroprevalence to adeno‐associated virus type 6 in people with hemophilia B from a UK adult cohort

Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 4, May 2022., 2022
Abstract Background Gene therapy shows promise as a potential “cure” for hemophilia A and B. Adeno‐associated virus (AAV) vectors are the leading platform to deliver modified genetic code of factor VIII or IX to the liver effecting endogenous production. Patient exposure to wild‐type AAV leads to the formation of neutralizing factors, which can prevent
Sara Boyce, Izabela James, Savita Rangarajan, Nicola Curry, Catherine Bagot, Steven Austin, Mike Laffan, Sarah Mangles, Kandiah Chandrakumaran, Carina Mundy   +9 more
wiley   +1 more source

Functional roles of the membrane-associated AAV protein MAAP

Scientific Reports, 2021
With a limited coding capacity of 4.7 kb, adeno-associated virus (AAV) genome has evolved over-lapping genes to maximise the usage of its genome. An example is the recently found ORF in the cap gene, encoding membrane-associated accessory protein (MAAP),
Lionel Galibert, Amira Hyvönen, Reetta A. E. Eriksson, Salla Mattola, Vesa Aho, Sami Salminen, Justin D. Albers, Sanna K. Peltola, Saija Weman, Tiina Nieminen, Seppo Ylä-Herttuala, Hanna P. Lesch, Maija Vihinen-Ranta, Kari J. Airenne   +13 more
doaj   +1 more source

Advancements in molecular design and bioprocessing of recombinant adeno‐associated virus gene delivery vectors using the insect‐cell baculovirus expression platform

Biotechnology Journal, Volume 16, Issue 4, April 2021., 2021
This review focus on the advancements of the molecular design of baculovirus vectors for high yield production of adeno‐associated virus (AAV) vectors for gene delivery describing the different generation of expression vectors with associated advantages and critical limitations.
Pranav R.H. Joshi, Alina Venereo‐Sanchez, Parminder S. Chahal, Amine A. Kamen   +3 more
wiley   +1 more source

Novel Mutant AAV2 Rep Proteins Support AAV2 Replication without Blocking HSV-1 Helpervirus Replication. [PDF]

PLoS ONE, 2017
As their names imply, parvoviruses of the genus Dependovirus rely for their efficient replication on the concurrent presence of a helpervirus, such as herpesvirus, adenovirus, or papilloma virus.
Michael Seyffert, Daniel L Glauser, Elisabeth M Schraner, Anna-Paula de Oliveira, Jorge Mansilla-Soto, Bernd Vogt, Hildegard Büning, R Michael Linden, Mathias Ackermann, Cornel Fraefel   +9 more
doaj   +1 more source

Construcción de un vector de expresión derivado de virus adenoasociados para corregir in vitro el defecto genético de la enfermedad de Morquio A

Biomédica: revista del Instituto Nacional de Salud, 2008
Introducción. La mucopolisacaridosis IV A (Morquio A) es una enfermedad de depósito lisosómico causada por la deficiencia en la actividad de la enzima N-acetil-galactosamina- 6-sulfato-sulfatasa que produce la acumulación intralisosómica de queratán y ...
Luis Alejandro Barrera, Mónica A. Gutiérrez, Felipe García Vallejo, Shunji Tomatsu, Flavio Cerón, Carlos J. Alméciga Díaz, Martha C. Domínguez   +6 more
doaj   +1 more source