Results 31 to 40 of about 843,401 (218)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

In-situ observation of twinning and grain rotation assisted deformation in wire-arc direct energy deposited (WDED) single phase titanium

Journal of Materials Research and Technology
Additive manufacturing of metals often results in microstructural inhomogeneities, leading to the simultaneous or sequential activation of multiple deformation mechanisms.
Blanca Palacios, Sohail M.A.K. Mohammed, Tanaji Paul, Brandon Aguiar, Sean Langan, Arvind Agarwal   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Widespread impacts to precipitation of the East Palestine Ohio train accident

Environmental Research Letters
On 3 February 2023, a Norfolk Southern train derailment occurred in East Palestine, Ohio. The accident and subsequent fire resulted in the emissions of large amounts of hazardous compounds to the ambient atmosphere over many days.
David A Gay, Katelan Blaydes, James J Schauer, Martin Shafer   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integrating parental genomes to reduce reference bias and identify intramuscular fat genes in Qinchuan Black pigs

Journal of Animal Science and Biotechnology
Background Traditional genomic analysis relies on a single reference genome, which struggles to effectively characterize the genetic diversity among populations. This is due to the substantial genetic differences between the genome of the studied species
Guangquan Lv, Peiyu Yang, Ao Guo, Minghao Cao, Dong Li, Zhe Liu, Mingyu Wang, Jingchun Sun, Rongrong Ding, Taiyong Yu   +9 more
doaj   +1 more source

Influences of welding speed on microstructure and mechanical properties of friction stir welded Al–Mg alloy with high Mg content

Materials Research Express, 2020
In this work, the influences of welding speed on microstructure and mechanical properties in friction stir welding (FSW) of the hot-rolled Al-9.2Mg-0.8Mn-0.2Zr-0.15Ti alloy plates has been investigated.
Yingli Li, Hongge Yan, Jihua Chen, Weijun Xia, Bin Su, Tian Ding, Xinyu Li   +6 more
doaj   +1 more source

Atmospheric Conditions for Uplift and Dust Transport in the Latitudinal 10° North–20° North Band in Africa

Atmosphere, 2022
Desert aerosols suspended in the atmosphere are a very marked fact in West Africa with estimates of 400 to 1000 million tons produced annually and concentrations exceeding 50 µg·m³ in Burkina.
Abdoulaye Bouya Diop, Malick Wade, Abdoulaye Sy, Abdoul Karim Mbodji, Abdou Karim Farota, El hadji Deme, Babacar Niang, Bouya Diop, Amadou Thierno Gaye, Aboubakary Diakhaby   +9 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source