Results 51 to 60 of about 843,401 (218)

The hybridization analysis of pedigree: whole-genome re-sequencing reveals genomics characterization and genetic basis of growth trait of Qinchuan black pigs

BMC Genomics
Background Understanding the genetic basis of hybridization trait between Chinese indigenous pig and their commercial relatives may contribute to germplasm innovation. The Qinchuan black (QCB) pig is a new composite breed under development generated from
Minghao Cao, Tiantian Yuan, Dong Li, Xiang Li, Yanyan Huang, Jingchun Sun, Yulong Wang, Taiyong Yu   +7 more
doaj   +1 more source

Coal measure gas co-generation and reservoir model and its geologic control effect in Upper Permian coal measure in South Sichuan area

Meitan kexue jishu
To investigate the unknown coexistence relationships and controlling factors for coal measure gas in the Upper Permian of the South Sichuan area, a systematic study was conducted on the characteristics of the reservoir lithological assemblage, the mode ...
Zhengxin HUANG, Xiaoli ZHANG, Zhaobiao YANG, Jinxian HE, Caiqin BI, Xuejuan SONG, Meng WU, Can LIANG   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Whole-genome resequencing reveals positive selection and introgression signatures and genetic loci associated with early puberty traits in Chinese indigenous pigs

Genetics Selection Evolution
Background The genetic basis of the phenotypic diversity of pigs is regulated by variants across the genome, especially the trait of early puberty, which is a crucial trait for enhancing the reproductive ability of pigs and the economy of the pig ...
Minghao Cao, Tiantian Yuan, Dong Li, Yulong Wang, Lin Zhang, Jingchun Sun, Guangquan Lv, Rongrong Ding, Taiyong Yu   +8 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Numerical Simulation Analysis of the Temperature Field of Molten Salt Linear Fresnel Collector

Energies
A complex operating environment and high operating temperature lead to the uneven temperature field distribution of key components of the molten salt Linear Fresnel collector in a way that compromises the collector’s safety and stability.
Linggang Kong, Yuan Niu, Duojin Fan, Minsen Shi, Ziyi Zheng   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Integrated multi-omics analysis reveals component differences and their regulatory mechanisms of adipose tissue as lard raw material between Bamei and Large White pigs

Food Science and Human Wellness
Bamei pigs, an indigenous Chinese breed, yield meat with a delectable flavor and boast higher carcass fat content compared to commercial breeds, making them a rich food source for humans.
Rui Li, Haozhe Han, Zihang Tie, Ran Wu, Mengmeng Bai, Mingyu Wang, Gongshe Yang, Weijun Pang, Rui Cai   +8 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source