Results 81 to 90 of about 1,322,802 (314)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Identification of different myofiber types in pigs muscles and construction of regulatory networks

BMC Genomics
Background Skeletal muscle is composed of muscle fibers with different physiological characteristics, which plays an important role in regulating skeletal muscle metabolism, movement and body homeostasis.
Chenchen Li, Yinuo Wang, Xiaohui Sun, Jinjin Yang, Yingchun Ren, Jinrui Jia, Gongshe Yang, Mingzhi Liao, Jianjun Jin, Xin’e Shi   +9 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Revealing genes related teat number traits via genetic variation in Yorkshire pigs based on whole-genome sequencing

BMC Genomics
Background Teat number is one of the most important indicators to evaluate the lactation performance of sows, and increasing the teat number has become an important method to improve the economic efficiency of farms.
Jialin Wei, Jingchun Sun, Yi Pan, Minghao Cao, Yulong Wang, Tiantian Yuan, Ao Guo, Ruihua Han, Xiangdong Ding, Gongshe Yang, Taiyong Yu, Rongrong Ding   +11 more
doaj   +1 more source

Improving genomic prediction accuracy of pig reproductive traits based on genotype imputation using preselected markers with different imputation platforms

Animal
Genomic prediction has been widely applied to the pig industry and has greatly accelerated the progress of genetic improvement in pigs. With the development of sequencing technology and price reduction, more and more genotype imputation panels of pig ...
J. Sun, J. Wei, Y. Pan, M. Cao, X. Li, J. Xiao, G. Yang, T. Yu   +7 more
doaj   +1 more source

Miocene deposits in Florida [PDF]

Science, 1885
n ...
openaire   +4 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Mammalia in Interglacial Deposits [PDF]

Science, 1885
n ...
openaire   +2 more sources

National Atmospheric Deposition Program 1999 Annual Summary

, 2000
is peer reviewedSubmitted by Susan Braxton (braxton@illinois.edu) on 2011-10-21T01:36:08Z No. of bitstreams: 1 99as.pdf: 3961577 bytes, checksum: 9fb922dc82ae589dda26787f2f49e13e (MD5)Made available in DSpace on 2011-10-21T01:36:08Z (GMT). No.
National Atmospheric Deposition Program
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