Results 91 to 100 of about 313,425 (309)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Resin‐coated urea effectively simulates the chronic dynamics of natural nitrogen deposition

Methods in Ecology and Evolution
Atmospheric nitrogen (N) deposition has more than tripled globally since the Industrial Revolution. Experiments usually simulate N deposition using fast‐release N fertilizers applied once or several times a year.
Yi Zhao, Yuguang Ke, Honghui Wu, Chong Xu, Xiwen Li, Yann Hautier, Elizabeth T. Borer, Qiang Yu   +7 more
doaj   +1 more source

Case report: Vesiculobullous eruption with an atypical IgA deposition pattern in a patient with multiple myeloma-A case report and literature review. [PDF]

Front Immunol, 2023
Li T, Liu H, Li W.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pulsed laser deposition and characterisation of rare earth doped glass-polymer optical materials [PDF]

, 2012
Tellurite glass is well known for its excellent optical properties in the application of optical fiber and planar waveguide devices, particularly for optical amplifiers. This thesis is focused on the design, fabrication and characterisation of tellurite
Zhao, Zhanxiang
core  

Influence of deposition strategy on the microstructure of volumetric WADED-fabricated AZ61 magnesium alloy components

Additive Manufacturing Letters
This study investigates the impact of various deposition strategies on the microstructure of volumetric components fabricated from AZ61 magnesium alloy using Wire Arc Direct Energy Deposition (WADED), also referred to as Wire Arc Additive Manufacturing ...
Filip Seidler, Jakub Slavíček, Daniel Koutný   +2 more
doaj   +1 more source

Solid Phase Deposition Pattern Concerning Formation Oil in YD 7 Reservoir of Tarim Oilfield and Its Application: A Case Study. [PDF]

ACS Omega, 2022
Wang J, Wu Y, He F, Guo P, Jiang H, Xu H.   +5 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Some aspects of pattern formation during electrochemical deposition of metals

, 2003
Department of Chemistry, D. D. U. Gorakhpur University, Gorakhpur-273 009, India E-mail: ishwar_das@rediffmail.com Fax: 91-551-342880 Manuscript received 20 September 2002 Some aspects of pattern formation during electrochemical deposition of ...
S. K. Gupta, lshwar Das, N. R. Agrawal, S. S. Mishra   +3 more
core   +1 more source

The response of sedimentation regime to changes in upstream runoff, based on modelling scenarios analysis in Lingdingyang Estuary, China

Frontiers in Marine Science
In recent decades, episodic extreme meteorological events have occurred frequently worldwide. Extreme drought and flood events have notably impacted on the evolution of large estuarine deltas, affecting estuarine geomorphology, human settlements, and ...
Kanglin Chen
doaj   +1 more source