Results 61 to 70 of about 295,234 (265)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Combinatory electric-field-guided deposition for spatial microparticles patterning

Materials Today Bio
Spatial deposition and patterning of microparticles are crucial in chemistry, medicine, and biology. Existing technologies like electric force manipulation, despite precise trajectory control, struggle with complex and personalized patterns.
Zhiyuan Zheng, Yang Zhang, Jinyu Xing, Xin Li, Zhiqiang Zhu, Min Ye, Shuwei Shen, Ronald X. Xu   +7 more
doaj   +1 more source

Accounting for the black carbon aging process in a two-way coupled meteorology–air quality model [PDF]

Atmospheric Chemistry and Physics
Black carbon (BC) exerts significant impacts on both climate and environment. The BC aging process alters its hygroscopicity and light absorption properties.
Y. Jin, Y. Jin, J. Wang, J. Wang, C. Liu, C. Liu, D. C. Wong, D. C. Wong, G. Sarwar, K. M. Fahey, S. Wu, S. Wu, J. Wang, J. Wang, J. Cai, J. Cai, J. Cai, Z. Tian, Z. Tian, Z. Zhang, Z. Zhang, J. Xing, A. Ding, A. Ding, S. Wang, S. Wang   +25 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

C5b9 Deposition in Glomerular Capillaries Is Associated With Poor Kidney Allograft Survival in Antibody-Mediated Rejection

Frontiers in Immunology, 2019
C4d deposition in peritubular capillaries (PTC) reflects complement activation in antibody-mediated rejection (ABMR) of kidney allograft. However, its association with allograft survival is controversial. We hypothesized that capillary deposition of C5b9—
Valentin Goutaudier, Hélène Perrochia, Simon Mucha, Marie Bonnet, Sylvie Delmas, Florian Garo, Valérie Garrigue, Sébastien Lepreux, Vincent Pernin, Vincent Pernin, Jean-Emmanuel Serre, Ilan Szwarc, Pierre Merville, Pierre Merville, Annie Ramounau-Pigot, Céline René, Jonathan Visentin, Jonathan Visentin, Bryan Paul Morgan, Véronique Frémeaux-Bacchi, Georges Mourad, Lionel Couzi, Lionel Couzi, Moglie Le Quintrec, Moglie Le Quintrec   +24 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Resin‐coated urea effectively simulates the chronic dynamics of natural nitrogen deposition

Methods in Ecology and Evolution
Atmospheric nitrogen (N) deposition has more than tripled globally since the Industrial Revolution. Experiments usually simulate N deposition using fast‐release N fertilizers applied once or several times a year.
Yi Zhao, Yuguang Ke, Honghui Wu, Chong Xu, Xiwen Li, Yann Hautier, Elizabeth T. Borer, Qiang Yu   +7 more
doaj   +1 more source

Influence of deposition strategy on the microstructure of volumetric WADED-fabricated AZ61 magnesium alloy components

Additive Manufacturing Letters
This study investigates the impact of various deposition strategies on the microstructure of volumetric components fabricated from AZ61 magnesium alloy using Wire Arc Direct Energy Deposition (WADED), also referred to as Wire Arc Additive Manufacturing ...
Filip Seidler, Jakub Slavíček, Daniel Koutný   +2 more
doaj   +1 more source