Results 61 to 70 of about 1,580,450 (269)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

INVESTMENT ATTRACTION THE DEVELOPMENT OF PEAT DEPOSITS ON THE EXAMPLE OF LENINGRAD REGION

Вестник Северо-Кавказского федерального университета, 2022
In the artikle presetet large number of unclaimed deposits ofpeat dictate the necessity to intensify their input in industrial development. Moreover, the scope of use ofpeat is very diverse and importantfor the regional economy in such branches as: small
Galina Peshkova
doaj  

Addams Crater, Venus, Venus: outflow analogous with a submarine debris flow? [PDF]

, 2005
The extraordinary outflow length and morphology of Addams crater deposits are compared with the Saharan submarine debris flow off Northwest Africa. Vapor cloud modelling and comparison of sonar data with radar images suggest a possible similar origin for
Petford, Nick, Purdie, P.
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Considerations on the management of banks with numerous branches in the common market countries. Variations on the theme of productivity

PSL Quarterly Review, 2014
The work is concerned with developing a general concept of productivity in banking. The study finds its origin in the simple observation that if the number of staff in large banks of different countries is divided by total balances or deposits, the ...
A. ROUX
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

New deposits [PDF]

Bank deposits ; Money ; Monetary policy - United States ; Money market deposit account ; Interest ...
John P. Judd
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

THE INFLUENCE OF GEOLOGY AND ORE DEPOSIT OCCURRENCE CONDITIONS ON DILUTION INDICATORS OF EXTRACTED RESERVES

Rudarsko-geološko-naftni Zbornik, 2019
The development of iron-ore deposits is accompanied by the excavation formation of considerable dimensions in the underground space and to ensure high technical and economic indicators of extraction, especially when developing high-grade iron ore, it is ...
Mykhailo Petlovanyi, Vasyl Lozynskyi, Serhii Zubko, Pavlo Saik, Kateryna Sai   +4 more
doaj   +1 more source

Opiate of Christ; or, John's Gospel and the Spectre of Class [PDF]

, 2016
This article applies a Libertarian Marxist lens to the Gospel of John. In doing so, it highlights the agrarian-aristocratic class struggle that is refracted in the text and also seeks to problematize hierarchi- cal and authoritarian ideologies. Its point
Robert Myles
core   +2 more sources