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Prevalence of Psychotropic Use and Psychotropic Polypharmacy in a Finnish National Cohort of Persons With Intellectual Disabilities

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Psychotropic use and psychotropic polypharmacy are common in people with intellectual disabilities, but representative population‐based studies on this topic are scarce. We evaluated the prevalence of psychotropic use and psychotropic polypharmacy in a Finnish nationwide cohort of people with intellectual disabilities aged 0–97 ...
Ville Virtanen +6 more
wiley +1 more source

Preventing Constipation in People Living With Dementia: Co‐Design of a Non‐Pharmacological Care Bundle for Residential Aged Care

Journal of Clinical Nursing, EarlyView.
ABSTRACT Aim(s) To develop a care‐bundle of non‐pharmacological strategies with the potential to prevent constipation in people with dementia in Residential Aged Care (RAC). Design Mixed‐methods intervention development study using Modified Delphi and co‐design, informed by evidence, current constipation prevention practices and stakeholder ...
Linda Schnitker +13 more
wiley +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley +1 more source

“Starting to think that way from the start”: approaching deprescribing decision-making for people accessing palliative care - a qualitative exploration of healthcare professionals views

BMC Palliative Care
Background Deprescribing has been defined as the planned process of reducing or stopping medications that may no longer be beneficial or are causing harm, with the goal of reducing medication burden while improving patient quality of life.
Anna Robinson-Barella +10 more
doaj +1 more source

Characteristics of elderly patients with polypharmacy who refuse to participate in an in-hospital deprescribing intervention: a retrospective cross-sectional study

BMC Geriatrics, 2018
Background Few studies have evaluated the characteristics of elderly patients with polypharmacy refusing deprescribing. The aim of this study was to evaluate the prevalence of potentially inappropriate medication (PIM) use in elderly patients accepting ...
Junpei Komagamine, Kenichi Sugawara, Kazuhiko Hagane +2 more
doaj +1 more source

Strengthening Pharmacovigilance Reporting for Withdrawal Reactions to Support Deprescribing

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 663-666, September 2026.
Pharmacovigilance plays a crucial role in post‐marketing surveillance of medicines and relies on the spontaneous reporting of adverse drug reactions (ADRs). Discontinuation of a drug can cause clinically relevant signs and symptoms, including withdrawal reactions; however, this subset of ADRs is not fully accommodated in current pharmacovigilance ...
Zakir Khan, Frank Moriarty
wiley +1 more source

Medication Growth Following Diagnosis of Intellectual and Developmental Disabilities at Varying Ages Throughout Childhood

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
ABSTRACT Purpose To characterize age‐related trajectories in psychotropic medication and polypharmacy use among children newly diagnosed with intellectual and developmental disabilities (IDD), addressing an evidence gap in longitudinal prescribing patterns.
Robert B. Christian +5 more
wiley +1 more source

Understanding stakeholders’ perspectives on implementing deprescribing for older people living in long-term residential care homes: the STOPPING study protocol

Implementation Science Communications, 2020
Background Older people with multimorbidity often experience polypharmacy. Taking multiple medicines can be beneficial; however, some older adults are prescribed multiple medicines when they are unlikely to improve clinical outcomes and may lead to harm.
Krystal Warmoth +8 more
doaj +1 more source

Prevalence of Benzodiazepine, Z‐Drug and Melatonin Use in Australian Residential Aged Care Facilities: A Systematic Review and Meta‐Analysis

Australasian Journal on Ageing, Volume 45, Issue 3, September 2026.
ABSTRACT Objectives To systematically examine the prevalence of, and factors associated with, benzodiazepine, Z‐drug and melatonin use in Australian residential aged care facilities (RACFs). Methods MEDLINE, Embase, CINAHL, PsycINFO, Scopus and International Pharmaceutical Abstracts were searched from January 2000 to February 2025 for studies reporting
Yuxing Joyce Liu +6 more
wiley +1 more source

The Development of a Framework to Support Ageing Well in the Torres Strait and Northern Peninsula Area of Australia

Australasian Journal on Ageing, Volume 45, Issue 3, September 2026.
ABSTRACT Objective Older Aboriginal and Torres Strait Islander Australians are central to their communities, providing cultural leadership and care. However, colonisation and systemic inequities have led to significant health disparities, with chronic diseases and dementia disproportionately affecting those aged over the age of 55 years.
Rachel Quigley +11 more
wiley +1 more source

polypharmacy
medicine
barriers

older adults
implementation
geriatrics

aged
primary care
qualitative