Results 71 to 80 of about 4,595 (134)

Deprescribing

, 2022
Deprescribing refers to reducing or stopping medications that may no longer be needed, may be causing more harm than good, or may not align with a patient’s healthcare goals and treatment preferences. This chapter provides a historical perspective on the
Thompson, Wade, Farrell, Barbara, Raman-Wilms, Lalitha   +2 more
core   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

Deprescribing in Danish clinical treatment guidelines [PDF]

, 2022
Lack of clinical guidance constitutes a significant barrier to deprescribing. Within Danish clinical guidelines on treatment of dementia, type 2 diabetes, hypertension, and osteoporosis, only limited attention was given to deprescribing.
Esmael, Arin, Alnabhan, Walaa Abdulmanem, Lundby, Carina; id_orcid, Søndergaard, Jens; id_orcid, Abuna, Larsa, Burghle, Alaa Hassan, Ryg, Jesper; id_orcid, Thanikaikumaran, Jinthusaa Kumaran, Pottegård, A; id_orcid   +8 more
core   +2 more sources

Prevalence of Psychotropic Use and Psychotropic Polypharmacy in a Finnish National Cohort of Persons With Intellectual Disabilities

Journal of Intellectual Disability Research, Volume 70, Issue 10, Page 1112-1124, October 2026.
ABSTRACT Background Psychotropic use and psychotropic polypharmacy are common in people with intellectual disabilities, but representative population‐based studies on this topic are scarce. We evaluated the prevalence of psychotropic use and psychotropic polypharmacy in a Finnish nationwide cohort of people with intellectual disabilities aged 0–97 ...
Ville Virtanen, Leena Saastamoinen, Maria Arvio, Hannu T. Vesala, Sonja Miettinen, Antti Teittinen, Anna‐Maija Tolppanen   +6 more
wiley   +1 more source

Mild Cognitive Impairment Diagnosis and Care Algorithms and the Role of Digital Interventions: Expert Consensus

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Mild cognitive impairment (MCI) carries a risk of further cognitive decline; thus, early diagnosis and intervention are important. The ASCEND Expert Group presents novel algorithms for (1) cognitive assessment/clinical diagnosis and (2) MCI management, emphasizing a multimodal strategy encompassing metabolic/cerebrovascular risk reduction, sensory loss
Nagaendran Kandiah, Yee Fai Chan, Darwin Dasig, Jacqueline Dominguez, Kar Chai Koh, Si Ching Lim, Paulus Anam Ong, Encarnita Raya‐Ampil, Raymond Chee Seong Seet, Vorapun Senanarong, Kit Mun Tan, Maw Pin Tan, Trần Công Thắng, Tong Mai Trang, Yuda Turana, Cuibai Wei, Ralf Ihl   +16 more
wiley   +1 more source

Strengthening Pharmacovigilance Reporting for Withdrawal Reactions to Support Deprescribing

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 663-666, September 2026.
Pharmacovigilance plays a crucial role in post‐marketing surveillance of medicines and relies on the spontaneous reporting of adverse drug reactions (ADRs). Discontinuation of a drug can cause clinically relevant signs and symptoms, including withdrawal reactions; however, this subset of ADRs is not fully accommodated in current pharmacovigilance ...
Zakir Khan, Frank Moriarty
wiley   +1 more source

Characteristics of elderly patients with polypharmacy who refuse to participate in an in-hospital deprescribing intervention: a retrospective cross-sectional study

BMC Geriatrics, 2018
Background Few studies have evaluated the characteristics of elderly patients with polypharmacy refusing deprescribing. The aim of this study was to evaluate the prevalence of potentially inappropriate medication (PIM) use in elderly patients accepting ...
Junpei Komagamine, Kenichi Sugawara, Kazuhiko Hagane   +2 more
doaj   +1 more source

Machine Learning Prediction of One‐Year Rehospitalization in Dementia: A Retrospective Cohort Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Patients with dementia have high rehospitalization rates, creating substantial clinical and economic burden. Machine learning (ML) may help predict readmission risk, but its use for clinically relevant outcomes such as rehospitalization in dementia remains limited.
Amirreza Esmaeili, Vahid Saeedi, Leila Kamalzadeh   +2 more
wiley   +1 more source

“Starting to think that way from the start”: approaching deprescribing decision-making for people accessing palliative care - a qualitative exploration of healthcare professionals views

BMC Palliative Care
Background Deprescribing has been defined as the planned process of reducing or stopping medications that may no longer be beneficial or are causing harm, with the goal of reducing medication burden while improving patient quality of life.
Anna Robinson-Barella, Charlotte Lucy Richardson, Zana Bayley, Andy Husband, Andy Bojke, Rona Bojke, Catherine Exley, Barbara Hanratty, Joanna Elverson, Jesse Jansen, Adam Todd   +10 more
doaj   +1 more source

What Matters Most: A Case of Pemphigus Vulgaris in a Nonagenarian Physician

Journal of the American Geriatrics Society, EarlyView.
Svetlana Bagdasarov, Loma Dave, Alan Sang, Lisa Zhou, Billie Fyfe‐Kirschner, Ying Guo, Ibiyonu Lawrence   +6 more
wiley   +1 more source