Results 61 to 70 of about 3,916,339 (374)

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Decreased diffusivity along the perivascular spaces in bipolar disorder: an MRI-based cross-sectional and Mendelian randomization study

Translational Psychiatry
The pathophysiology of bipolar disorder (BD) remains unclear. We investigated whether diffusion tensor imaging along perivascular spaces (DTI-ALPS), a putative MRI marker of glymphatic function, is altered in BD and whether this index relates to ...
Zhuohui Chen, Ziwei Teng, Yan Qiu, Sujuan Li, Xuelei Xu, Min Yang, Jindong Chen, Dong Yang, Hao Li   +8 more
doaj   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Depression and its association with psychological factors among adolescents living with HIV in Southwestern Nigeria

BMC Psychiatry, 2023
Objective The aim was to determine the prevalence of depressive disorder and associated psychological factors among adolescents living with HIV/AIDS. Methods One hundred and five adolescents with HIV were assessed for self-esteem, internalized HIV stigma
Lawal RO, Adesanmi Akinsulore, Oginni OA, Aloba OO, Mosaku SK, Akanmu AS   +5 more
doaj   +1 more source

Effects of neurofeedback on major depressive disorder: a systematic review

Einstein (São Paulo), 2023
Background Major depressive disorder is a difficult-to-treat psychological disorder. Approximately 30% of patients with major depressive disorder do not respond to conventional therapies; thus, the efficacy of alternative therapies for treating major ...
Isabelly Cristine de Souza Dobbins, Murilo Bastos, Renan Cassiano Ratis, Weber Claúdio Francisco Nunes da Silva, Juliana Sartori Bonini   +4 more
doaj   +1 more source

Psychiatric diagnosis in attempted suicide [PDF]

, 2006
This is a retrospective study which assesses the various socio-demographic correlates, the methods adopted to commit suicide and the psychiatric disorders in patients attempting suicide.
Baby, Sanjush, KF, Yesudas, P, Manju
core  

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

A systematic review and meta-analysis of psychological burden in family caregivers of patients with brain tumors

Scientific Reports
Family caregivers of brain tumor patients often experience severe psychological problems, with a high prevalence of mental health issues posing a growing challenge in clinical practice.
Haiyu Chen, Tianxiang Zou, Ziwei Teng, Yue Qin, Yizhi Deng, Renrong Wu, Jing Huang, Qiong Luo   +7 more
doaj   +1 more source

Association between allergic diseases, generalized anxiety disorder, and depressive symptoms in South Korean adolescents: a secondary data analysis of the 2022 Korea Youth Risk Behavior Survey [PDF]

Child Health Nursing Research
Purpose This study investigated the relationship between allergic diseases, general anxiety disorder, and depressive symptoms among Korean adolescents.
Jaeyoung Lee, So Yeon Park
doaj   +1 more source

White Matter Alterations in Depressive Disorder

Frontiers in Immunology, 2022
Depressive disorder is the most prevalent affective disorder today. Depressive disorder has been linked to changes in the white matter. White matter changes in depressive disorder could be a result of impaired cerebral blood flow (CBF) and CBF self ...
Enling He, Min Liu, Sizhu Gong, Xiyao Fu, Yue Han, Fang Deng   +5 more
doaj   +1 more source