Results 81 to 90 of about 11,747 (273)

U.S. Banking Deregulation, Small Businesses,and Interstate Insurance of Personal Income [PDF]

open access: yes
We estimate the effects of deregulation of U.S. banking restrictions on the amount of interstate personal income insurance during the period 1970–2001. Interstate income insurance occurs when personal income reacts less than one-to-one to state-specific ...
Bent E. Sørensen   +2 more
core  

TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNA

open access: yesAdvanced Science, EarlyView.
We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li   +10 more
wiley   +1 more source

Triptolide Administration Alters Immune Responses to Mitigate Insulin Resistance in Obese States

open access: yesBiomolecules
Individuals who are overweight or obese are at increased risk of developing prediabetes and type 2 diabetes, yet the direct molecular mechanisms that connect diabetes to obesity are not clear.
Lyudmila Grodsky   +3 more
doaj   +1 more source

Dynamic Modeling and Analysis of the Cross-Talk between Insulin/AKT and MAPK/ERK Signaling Pathways.

open access: yesPLoS ONE, 2016
Feedback loops play a key role in the regulation of the complex interactions in signal transduction networks. By studying the network of interactions among the biomolecules present in signaling pathways at the systems level, it is possible to understand ...
Yaman Arkun
doaj   +1 more source

Monetary Strategies from the Perspective of Intermediate Objectives [PDF]

open access: yes
Central bank can apply different kinds of monetary strategies. This paper analyses monetary strategy from the perspective of intermediate objectives. Right strategy should help to fulfil targeted goals. However, it is not easy to choose right strategy in
Ján Vravec, Marianna Neupauerová
core  

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang   +12 more
wiley   +1 more source

ENTREPRENEURIAL CULTURE, PROFILE OF THE LEADER AND ENTREPRENEURIAL ORIENTATION: EMPIRICAL APPLICATION IN THE CASE OF THE TUNISIAN COMPANIES [PDF]

open access: yesStrategii Manageriale, 2013
Today, no company is safe from forces and pressures, which are exerted on it, because of a significant number of the requirements in particular as regards competitiveness, the need for change, or the crises, the deregulations and the cost of energy.
Mighri ZOUHAYER
doaj  

Emerging Religious Marketplace in Nigeria: A Quest for Interpretation [PDF]

open access: yes, 2014
In contemporary Nigerian society, the evolving trends in Christian religious culture suggest that neoliberal (social) mind-set is influencing certain practices in many Churches.
Duke, Emmanuel Orok
core  

Mineralized Cryogel/Hydrogel Constructs to Recapitulate Early Breast Cancer Bone Metastasis In Vitro

open access: yesAdvanced Science, EarlyView.
A new biphasic in vitro cryogel/hydrogel model of early breast cancer bone metastasis provides precise control over microenvironmental cues and microscopic access to the spatiotemporal cancer cell distribution. Deposited bone‐like mineral is observed to strongly impede the effects of biomolecular signals, as evidenced by both colonization profiles and ...
Jana Sievers‐Liebschner   +8 more
wiley   +1 more source

Oncolytic virotherapy

open access: yesAnnals of Hepatology, 2008
Current oncolytic virotherapy strategies are based in the accumulated understanding of the common molecular mechanisms displayed during cell transformation and viral infection, like cell cycle and apoptosis deregulations.
Daniel Cervantes-García;   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy