Results 91 to 100 of about 5,433 (281)

Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies

open access: yesParkinson's Disease, 2012
Parkinson's disease is the second common neurodegenerative disorder, after Alzheimer's disease. It is a clinical syndrome characterized by loss of dopamine-generating cells in the substancia nigra, a region of the midbrain.
José M. Bravo-San Pedro   +5 more
doaj   +1 more source

Proteomic and functional deregulations in Philadelphia negative Myeloproliferative Neoplasms

open access: yes, 2015
En plus des anomalies génétiques, plusieurs études ont rapporté des altérations des protéines chez les patients atteintes de Syndromes Myéloprolifératifs (SMP) Ph- qui pourraient participer à leurs phénotypes cliniques.
Socoro Yuste, Nuria
core  

Biomarkers of lung congestion and injury in acute heart failure

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi   +9 more
wiley   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

open access: yesEpilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze   +19 more
wiley   +1 more source

Structural Reforms and Growth: Product and Labor Market Deregulations

open access: yes
The paper focuses on labor and product market deregulations, as fundamental elements in the passage from an investment to an innovation-based economy. The approach undertaken is prominently empirical.
Eijffinger, Sylvester C W   +1 more
core   +1 more source

Corporate Taxation and the Size of New Firms: Evidence From Europe

open access: yes
Using a novel country-industry level panel database with information on newly incorporated firms in 17 European countries between 1997 and 2004, we study how taxation of corporate income affects the size of entrants at the country-industry level.
Di Giacomo, M.   +2 more
core  

Identifying and Targeting Molecular Deregulations In Uterine Leiomyosarcoma: A Role For Mtor Inhibition-Based Combination Therapies

open access: yes, 2012
Uterine leiomyosarcoma (ULMS) is an aggressive malignancy characterized by marked chemoresistance, frequent relapses, and poor outcome. Despite efforts to improve survival over the past several decades, only minimal advances have been made.
Brewer Savannah, Kari Jo
core  

Smart Charging With Hourly Pricing as Policy Intervention: Reducing Costs and Grid Congestion for Promoting Electric Vehicles in Developing Countries

open access: yesEnergy Science &Engineering, EarlyView.
Smart charging with hourly pricing optimizes electric vehicle (EV) charging in developing countries, reducing EV owner costs by 30% and easing grid congestion. Using an agent‐based energy management system, the study shows dynamic pricing effectively shifts charging to off‐peak hours, enhancing grid stability and supporting sustainable EV adoption in ...
Maha Iftikhar   +8 more
wiley   +1 more source

Managing for resilience with ecological structure: Portfolio effects in the Laurentian Great Lakes

open access: yesFrontiers in Ecology and the Environment, EarlyView.
Combined effects of global change, including land conversion, biological invasions, and overexploitation, have degraded the resilience of ecosystems and the services they provide. Here, we identify key ecological structures and processes that can be targeted by management to improve resilience at scales ranging from single species to entire landscapes.
Kayla RS Hale   +15 more
wiley   +1 more source

Revisiting Swedish Postmodernism : Gendered Architecture and Other Stories

open access: yes, 2016
The years around 1980 contained dynamic architectural discourse in Swedish history covering contradictory ideas all sharing the critique of functionalism. Revisiting the discussions today implies a reconsideration of the historiographical self-conception,
Mattsson, Helena,
core   +1 more source

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