Results 71 to 80 of about 1,072,002 (279)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fitting of parameters for a temperature control model by means of continuous derivative-free optimization: a case study in a broiler house

Bulletin of Computational Applied Mathematics, 2017
Intensive broiler production requires of accurate control systems aimed to maintain ideal conditions inside the facilities. The achievement of an appropriate environment guarantees good performance and sustainability of the production.
Bruno H. Cervelin, Dante Conti, Denise T. Detsch, Maria A. Diniz-Ehrhardt, José Mario Martínez   +4 more
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Novel Techniques with Memory Extension of Three-Step Derivative-Free Iterative Scheme for Nonlinear Systems

Computation
This article presents the development of three-step derivative-free techniques with memory, which achieve higher convergence orders for solving systems of nonlinear equations.
Nishant Kumar, Jai P. Jaiswal, Ioannis K. Argyros   +2 more
doaj   +1 more source

A Family of Derivative-Free Methods with High Order of Convergence and Its Application to Nonsmooth Equations

Abstract and Applied Analysis, 2012
A family of derivative-free methods of seventh-order convergence for solving nonlinear equations is suggested. In the proposed methods, several linear combinations of divided differences are used in order to get a good estimation of the derivative of the
Alicia Cordero, José L. Hueso, Eulalia Martínez, Juan R. Torregrosa   +3 more
doaj   +1 more source

Slow and steady wins the race: Approximating Nash equilibria in nonlinear quadratic tracking games [PDF]

, 2015
We propose a meta-heuristic approach for solving nonlinear dynamic tracking games. In contrast to more "traditional" methods based on linear-quadratic (LQ) techniques, this derivative-free method is very flexible (e.g. to introduce inequality constraints)
Blueschke, Dmitri, Blueschke-Nikolaeva, Victoria, Savin, Ivan   +2 more
core  

StepDIRECT - A Derivative-Free Optimization Method for Stepwise Functions

, 2022
In this paper, we propose the StepDIRECT algorithm for derivative-free optimization (DFO), in which the black-box objective function has a stepwise landscape. Our framework is based on the well-known DIRECT algorithm. By incorporating the local variability to explore the flatness, we provide a new criterion to select the potentially optimal hyper ...
Phan, Dzung T., Liu, Hongsheng, Nguyen, Lam M.   +2 more
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source