Results 51 to 60 of about 253,815 (263)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Calibrating the GAMIL3-1° climate model using a derivative-free optimization method [PDF]

Geoscientific Model Development
Parameterization in climate models often involves parameters that are poorly constrained by observations or theoretical understanding alone. Manual tuning by experts can be time-consuming, subjective, and prone to underestimating uncertainties. Automated
W. Liang, W. Liang, W. Liang, S. F. B. Tett, L. Li, C. Cartis, D. Xu, W. Dong, W. Dong, J. Huang, J. Huang   +10 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

On the semilocal convergence of derivative free methods for solving nonlinear equations

Journal of Numerical Analysis and Approximation Theory, 2012
We introduce a Derivative Free Method (DFM) for solving nonlinear equations in a Banach space setting. We provide a semilocal convergence analysis for DFM using recurrence relations. Numerical examples validating our theoretical results are also provided
Ioannis K. Argyros, Hongmin Ren
doaj   +2 more sources

A Second-Order Finite-Difference Method for Derivative-Free Optimization

Journal of Mathematics
In this paper, a second-order finite-difference method is proposed for finding the second-order stationary point of derivative-free nonconvex unconstrained optimization problems.
Qian Chen, Peng Wang, Detong Zhu
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Sequential Penalty Derivative-Free Methods for Nonlinear Constrained Optimization

SIAM Journal on Optimization, 2010
We consider the problem of minimizing a continuously differentiable function of several variables subject to smooth nonlinear constraints. We assume that the first order derivatives of the objective function and of the constraints can be neither calculated nor explicitly approximated.
LIUZZI, Giampaolo, LUCIDI, Stefano, Marco Sciandrone   +2 more
openaire   +7 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Convergence Analysis and Complex Geometry of an Efficient Derivative-Free Iterative Method

Mathematics, 2019
To locate a locally-unique solution of a nonlinear equation, the local convergence analysis of a derivative-free fifth order method is studied in Banach space.
Deepak Kumar, Janak Raj Sharma, Lorentz Jäntschi   +2 more
doaj   +1 more source