Results 71 to 80 of about 264,051 (290)

A Derivative-Free Observability Analysis Method of Stochastic Power Systems

, 2021
The observability analysis of a time-varying nonlinear dynamic model has recently attracted the attention of power engineers due to its vital role in power system dynamic state estimation.
Mert Korkali, Yijun Xu, Zheng, Zongsheng, Zongsheng Zheng, Zhigang Liu, Korkali, Mert, Xu, Yijun, Mili, Lamine M., Liu, Zhigang, Lamine Mili, Yuhong Wang, Wang, Yuhong   +11 more
core   +1 more source

About the Performance of a Calculus-Based Approach to Building Model Functions in a Derivative-Free Trust-Region Algorithm

Algorithms, 2023
This paper examines a calculus-based approach to building model functions in a derivative-free algorithm. This calculus-based approach can be used when the objective function considered is defined via more than one blackbox.
Warren Hare, Gabriel Jarry-Bolduc
doaj   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Calibrating the GAMIL3-1° climate model using a derivative-free optimization method [PDF]

Geoscientific Model Development
Parameterization in climate models often involves parameters that are poorly constrained by observations or theoretical understanding alone. Manual tuning by experts can be time-consuming, subjective, and prone to underestimating uncertainties. Automated
W. Liang, W. Liang, W. Liang, S. F. B. Tett, L. Li, C. Cartis, D. Xu, W. Dong, W. Dong, J. Huang, J. Huang   +10 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

On the semilocal convergence of derivative free methods for solving nonlinear equations

Journal of Numerical Analysis and Approximation Theory, 2012
We introduce a Derivative Free Method (DFM) for solving nonlinear equations in a Banach space setting. We provide a semilocal convergence analysis for DFM using recurrence relations. Numerical examples validating our theoretical results are also provided
Ioannis K. Argyros, Hongmin Ren
doaj   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Derivative free stochastic discrete gradient method with adaptive mutation

, 2006
In data mining we come across many problems such as function optimization problem or parameter estimation problem for classifiers for which a good learning algorithm for searching is very much necessary.
Ranadhir Ghosh, Ghosh, Ranadhir, Ghosh, Moumita, Moumita Ghosh, Adil Bagirov, Bagirov, Adil   +5 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source