Results 51 to 60 of about 14,414,832 (247)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

About the Performance of a Calculus-Based Approach to Building Model Functions in a Derivative-Free Trust-Region Algorithm

Algorithms, 2023
This paper examines a calculus-based approach to building model functions in a derivative-free algorithm. This calculus-based approach can be used when the objective function considered is defined via more than one blackbox.
Warren Hare, Gabriel Jarry-Bolduc
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

A derivative-free method for bilevel optimization [PDF]

, 2023
openThe goal is to design, under the assumption of having access to an approximation of the lower-level minimizer, derivative-free methods in order to solve the upper-level. The focus is on optimization with constraints, both in the smooth and non-smooth
BOJOVIC, MATIA
core  

On the semilocal convergence of derivative free methods for solving nonlinear equations

Journal of Numerical Analysis and Approximation Theory, 2012
We introduce a Derivative Free Method (DFM) for solving nonlinear equations in a Banach space setting. We provide a semilocal convergence analysis for DFM using recurrence relations. Numerical examples validating our theoretical results are also provided
Ioannis K. Argyros, Hongmin Ren
doaj   +2 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A Second-Order Finite-Difference Method for Derivative-Free Optimization

Journal of Mathematics
In this paper, a second-order finite-difference method is proposed for finding the second-order stationary point of derivative-free nonconvex unconstrained optimization problems.
Qian Chen, Peng Wang, Detong Zhu
doaj   +1 more source

Calibrating the GAMIL3-1° climate model using a derivative-free optimization method [PDF]

Geoscientific Model Development
Parameterization in climate models often involves parameters that are poorly constrained by observations or theoretical understanding alone. Manual tuning by experts can be time-consuming, subjective, and prone to underestimating uncertainties. Automated
W. Liang, W. Liang, W. Liang, S. F. B. Tett, L. Li, C. Cartis, D. Xu, W. Dong, W. Dong, J. Huang, J. Huang   +10 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

On Derivative-Free Optimisation Methods [PDF]

, 2023
As part of the field of mathematical optimisation, derivative-free optimisation is the study of optimisation methods that are not granted full access to the derivative of the objective function. In this master's thesis, three derivative-free optimisation
Heeman, Pim
core