Results 61 to 70 of about 965,091 (147)

A Novel Workflow for Non-Animal PBK Modelling of UV Filters: Oxybenzone as a Case Study

Pharmaceuticals
Background/Objectives: Physiologically based kinetics (PBK) modelling provides (internal) exposure concentrations. We used a PBK model parameterized exclusively with in silico and in vitro data in a bottom-up approach to predict the pharmacokinetics of ...
Nazanin Golbamaki, Anne Moustié, Nicola J. Hewitt, Guillaume Lereaux, Matthew Burbank, El Mehdi Ben Yahya, Sébastien Grégoire, Laurène Roussel-Berlier   +7 more
doaj   +1 more source

Assessment of the health risks of some potentially toxic elements’ (PTEs) intake via soil particles from a grassless sports facility in Abakaliki, Ebonyi State, Nigeria

Discover Environment
The concentrations of some PTEs in soils from a grassless sports facility in Abakaliki, Ebonyi State, were assessed to predict the health risks that may be associated with their intake as particles through inhalation and dermal absorption.
Godwin Nkwuda Nwonumara, Onyeka J. Ogbonna, Florence Amarachineke Elebe, Rita Ogodo Nwankwegu, Okechukwu Idumah Okogwu   +4 more
doaj   +1 more source

Radiofrequency Microneedling-Mediated Enhancement in Percutaneous Delivery of Topical Triamcinolone Acetonide: An In Vivo Quantitative Study

Life
Background: The stratum corneum (SC) limits the efficacy of topical corticosteroids. Radiofrequency microneedling (RFMN) may enhance drug delivery; however, quantitative in vivo human data remain limited.
Rosalyn Kupwiwat, Rungsima Wanitphakdeedecha, Teerapat Wannawittayapa, Panyapat Buranaporn, Poonsin Poungpairoj, Theeraporn Maneesawat, Varangkana Tantithavorna, Premrutai Thitilertdecha   +7 more
doaj   +1 more source

Dermal tissue remodeling and non-osmotic sodium storage in kidney patients

Journal of Translational Medicine, 2019
Background Excess dietary sodium is not only excreted by the kidneys, but can also be stored by non-osmotic binding with glycosaminoglycans in dermal connective tissue. Such storage has been associated with dermal inflammation and lymphangiogenesis.
Ryanne S. Hijmans, Marco van Londen, Kwaku A. Sarpong, Stephan J. L. Bakker, Gerjan J. Navis, Twan T. R. Storteboom, Wilhelmina H. A. de Jong, Robert A. Pol, Jacob van den Born   +8 more
doaj   +1 more source

Variability Between Datasets and Statistical Approaches—Rethinking Estimation of Default Dermal Absorption Values for Risk Assessment

Toxics
In risk assessment, deriving dermal absorption values is essential for evaluating plant protection products. Applicants submit study data, which authorities assess during the authorisation process.
Veronika Städele, Sabine Martin, Korinna Wend   +2 more
doaj   +1 more source

In silico model to predict dermal absorption of chemicals in finite dose conditions [PDF]

The development of in silico approaches that can estimate the dermal absorption of chemicals exposed in practical conditions is highly anticipated. In the present study, an in silico model to estimate both the dermal absorption rate and dermal permeation
杉林, 堅次, 押坂, 勇志, 板倉, 祥子, 成田, 伊吹, 寺前, 裕之, 藤堂, 浩明, 藤原, 知洋, 小松, 周平, 高山, 幸三   +8 more
core   +1 more source

Identification, Quantification, and Characterization of Microplastics in Skincare and Treatment Creams: A Potential Health Concern Related to the Exposure Pathway

Journal of Xenobiotics
This research aimed to quantify and investigate the morphology of microplastics in skincare and treatment creams related to their chemical composition and the potential risks to human health associated with exposure to microplastics by dermal contact.
Raluca Maria Stirbescu, Cristiana Radulescu, Raluca Maria Bucur (Popa), Andreea Laura Banica, Ioan Alin Bucurica, Ioana Daniela Dulama   +5 more
doaj   +1 more source

Cetuximab associated dermal filler reaction

, 2019
A 52-year-old male patient with hyaluronic acid-based dermal fillers injected in his cheeks was diagnosed with glossotonsillary malignancy, and managed with concurrent cetuximab (epidermal growth factor receptor inhibitor) and radiation therapy.
Dzienis, Marcin, Pathmanathan, Shivanshan   +1 more
core   +1 more source

Skin permeability and pharmacokinetics of diclofenac epolamine administered by dermal patch in Yorkshire-Landrace pigs

Journal of Pain Research, 2012
Susanna Tse,1 Kendall D Powell,2 Stephen MacLennan,3 Allan R Moorman,4 Craig Paterson,5 Rosonald R Bell11Pfizer Inc, Groton, CT, USA; 2Tandem Labs, Durham, NC, USA; 3BioCryst Pharmaceuticals Inc, Durham, NC, USA; 4Alta Vetta Pharmaceutical Consulting LLC,
Tse S, Powell KD, MacLennan SJ, Moorman AR, Paterson C, Bell RR   +5 more
doaj  

The in vitro plasticity of hair follicle dermal and mesenchymal stem cells [PDF]

, 2008
Stem cells from the hair follicle are an easily accessible population of cells that have a broad in vitro developmental capabilities and potential for autologous replacement of damaged adult tissue.
Emmerson, Robert
core