Results 91 to 100 of about 272,773 (298)

Magnetic gelatin-hesperidin microrobots promote proliferation and migration of dermal fibroblasts

Frontiers in Chemistry
Dermal fibroblasts play a crucial role in the formation of granulation tissue in skin wounds. Consequently, the differentiation, migration, and proliferation of dermal fibroblasts are considered key factors in the skin wound healing process.
Xuyan Sun, Hua Yang, Han Zhang, Weiwei Zhang, Chunyu Liu, Xiaoxiao Wang, Wenping Song, Lin Wang, Qingsong Zhao   +8 more
doaj   +1 more source

Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages

Frontiers in Immunology, 2019
Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E2 (PGE2).
Jorge Arasa, Jorge Arasa, María Carmen Terencio, María Carmen Terencio, Rosa María Andrés, Rosa María Andrés, Asunción Marín-Castejón, Asunción Marín-Castejón, Francisca Valcuende-Cavero, Francisca Valcuende-Cavero, Miguel Payá, Miguel Payá, María Carmen Montesinos, María Carmen Montesinos   +13 more
doaj   +1 more source

Human gingival fibroblast secretome accelerates wound healing through anti-inflammatory and pro-angiogenic mechanisms

npj Regenerative Medicine, 2020
Healing of the skin and oral mucosa utilises similar mechanisms of tissue repair, however, scarring and the rate of wound closure is vastly superior in the oral cavity suggesting differences between these two environments.
Parinaz Ahangar, Stuart J. Mills, Louise E. Smith, Stan Gronthos, Allison J. Cowin   +4 more
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Mechanical Programming of PEGDA‐β‐CD Polyrotaxane‐Based Hydrogels via Host–Guest Molecular Recognition

Advanced Functional Materials, EarlyView.
A mechanically programmable hydrogel for tissue engineering is developed by modulating the molecular threading density of poly(ethylene glycol) diacrylate‐β‐cyclodextrin (PEGDA‐β‐CD) polyrotaxane and combining it with β‐CD‐modified gelatin. The polyrotaxane‐guided transition from disordered pores to laminar microstructures enables precise tuning ...
Shiyi Chen, Xudan Xing, Haopu Su, Dominik Voll, Xiaohe Xu, Jiafeng Wan, Tongtong Cui, Christian W. Schmitt, Stefan Bräse, Peng Li, Patrick Théato   +10 more
wiley   +1 more source

Keratinocyte-driven dermal collagen formation in the axolotl skin

Nature Communications
Type I collagen is a major component of the dermis and is formed by dermal fibroblasts. The development of dermal collagen structures has not been fully elucidated despite the major presence and importance of the dermis. This lack of understanding is due
Ayaka Ohashi, Hirotaka Sakamoto, Junpei Kuroda, Yohei Kondo, Yasuhiro Kamei, Shigenori Nonaka, Saya Furukawa, Sakiya Yamamoto, Akira Satoh   +8 more
doaj   +1 more source

Osteogenic differentiation of human dermal fibroblasts

, 2008
Approximately 1.5 million bone graft procedures are performed annually in the United States. Given limitations in current bone graft technology, tissue engineering represents an alternate strategy to repair damaged or diseased tissues.
Hee, Christopher K
core  

Biological implications of a discrete mathematical model for collagen deposition and alignment in dermal wound repair [PDF]

, 2000
We deveiop a novel mathematical model for collagen deposition and alignment during dermal wound healing. We focus on the interactions between fibroblasts, modelled as discrete entities, and a continuous extracellular matrix composed of collagen and a ...
Dallon, J. C., Maini, P K, Sherratt, J. A., Ferguson, M, Maini, P. K., Maini, P., Dallon, J C, Dallon, J., Sherratt, Jonathan Adam, Sherratt, J., Ferguson, M.   +10 more
core   +1 more source

Preferential Interfacial Engineering of Hydrogels via Interdigitated Nanoparticle Assembly

Advanced Functional Materials, EarlyView.
Robust surface functionalization of hydrogel surfaces is performed via interdigitated metal nanoparticle assembly, inducing strong affinity with the hydrogel matrix. The partially exposed nanoparticle domains act as interfacial nanobridges that mediate both chemical and physical bonding with diverse materials, including small molecules, fluorous ...
Hyeonjin Kim, Hyeseoung Lim, Ji Min Lee, Heeyeon Kang, Yongkwon Song, Woojae Chang, So‐Jin Park, Jin Yoo, Atsushi Hozumi, Jinhan Cho, Jongkuk Ko, Sanghyuk Wooh   +11 more
wiley   +1 more source

Human Galectins Induce Conversion of Dermal Fibroblasts into Myofibroblasts and Production of Extracellular Matrix: Potential Application in Tissue Engineering and Wound Repair [PDF]

, 2011
Members of the galectin family of endogenous lectins are potent adhesion/growth-regulatory effectors. Their multi-functionality opens possibilities for their use in bioapplications. We studied whether human galectins induce the conversion of human dermal
Lacina, Lukas, André, Sabine, Kaltner, Herbert, Karel Smetana, Jr., Gabius, Hans-Joachim, Peter Gal, Szabo, Pavol, Eva Sykova, Gal, Peter, Zima, Tomas, Sabine André, Tomas Zima, Smetana, Karel, Pavol Szabo, Barbora Dvořánková, Dvorankova, Barbora, Hans-Joachim Gabius, Jana Uhrova, Sykova, Eva, Lukas Lacina, Uhrova, Jana, Herbert Kaltner   +21 more
core   +1 more source