Results 131 to 140 of about 272,773 (298)

FibroPrep protocol for rapid enzyme-free isolation of primary dermal fibroblasts from adult mouse skin for biological assays

STAR Protocols
Summary: Isolating primary dermal fibroblasts is often costly, time-consuming, has high contamination risk, and is inefficient, yielding low cell numbers and requiring long culture periods.
Shubhangi Chakraborty, Supratim Pradhan, Deneshraj Srinivasan, Budhaditya Mukherjee   +3 more
doaj   +1 more source

Autonomous Reconfigurable Modular Conductive Hydrogels for Adaptive and Degradable Bioelectronic Interfaces

Advanced Materials Technologies, EarlyView.
Bridging rigid electrodes with soft, irregular tissues demands more than conductivity alone. Modular conductive hydrogels autonomously reconfigure into conformal electrode‐tissue interfaces, coupling mixed ionic‐electronic conduction with tissue‐like mechanics, self‐healing, and degradability.
Matthew K. Burgess, Zofia B. Wolny, Zekun Liu, Karolina Cysewska, Malavika Nair   +4 more
wiley   +1 more source

Human Dermal Fibroblasts in Tissue Engineering

, 2009
The loss or failure of tissues and/or organs is one of the most frequent problems in modern healthcare. The field of tissue engineering applies the principles of biology and engineering in order to develop functional substitutes for damaged tissues ...
Junker, Johan
core   +2 more sources

Wireless Precise Manipulation of Tumor Spheroids Using a Millirobot Controlled by Permanent Magnetic Traps

Advanced Robotics Research, EarlyView.
A magnetic donut‐like millirobot is developed for label‐free pick‐and‐place of a tumor spheroid wirelessly controlled by a magnetic trap. Spheroids are important 3D multicellular culture systems that recapitulate key structural and functional features of native tissues.
Yue Gao, Moonkwang Jeong, Anni G. Muñoz, Ann‐Sophia Müller, Fangchao Long, Shengqiang Zhou, Juntian Qu, Leoni A. Kunz‐Schughart, Tian Qiu   +8 more
wiley   +1 more source

The role of dermal fibroblasts in autoimmune skin diseases

Frontiers in Immunology
Fibroblasts are an important subset of mesenchymal cells in maintaining skin homeostasis and resisting harmful stimuli. Meanwhile, fibroblasts modulate immune cell function by secreting cytokines, thereby implicating their involvement in various dermatological conditions such as psoriasis, vitiligo, and atopic dermatitis.
Zeqi Shi, Zhong Liu, Yujia Wei, Ri Zhang, Yunhua Deng, Dong Li   +5 more
openaire   +3 more sources

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

UVB irradiation on human dermal fibroblasts

UVB is a primary contributor to extrinsic skin aging, and a comprehensive understanding of its impact on human skin is crucial for elucidating the aging process and facilitating the development of effective drug treatments.
Liu, Li
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

In vitro investigations on the effect of dermal fibroblasts on keratinocyte responses to ultraviolet B radiation

, 2014
Exposure to ultraviolet radiation is closely linked to the development of skin cancers in humans. The ultraviolet B (UVB) radiation wavelength (280-320 nm), in particular, causes DNA damage in epidermal keratinocytes, which are linked to the generation ...
Van Lonkhuyzen, D R, Upton, Z, Kimlin, Michael G., Fernandez, T L, Kimlin, Michael G, Fernandez, Tara L., Dawson, R A, Van Lonkhuyzen, Derek R., Dawson, Rebecca A., Upton, Zee   +9 more
core   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source