Results 61 to 70 of about 281,777 (272)

Formulation and characterization of dermal patch containing mangosteen (Garcinia mangostana L.) peel extract using ethyl cellulose and polyvinylpyrrolidone polymers

Pharmaciana
Mangosteen peel extract (Garcinia mangostana L.) shows strong potential in treating diabetic ulcers. Topical applications via dermal patches enable direct delivery of active compounds while protecting wounds from contaminants, preventing bacterial ...
Ni Luh Dewi Aryani, Rismawati, Marisca Evalina Gondokesumo   +2 more
doaj   +5 more sources

Skin permeability and pharmacokinetics of diclofenac epolamine administered by dermal patch in Yorkshire-Landrace pigs

Journal of Pain Research, 2012
Susanna Tse,1 Kendall D Powell,2 Stephen MacLennan,3 Allan R Moorman,4 Craig Paterson,5 Rosonald R Bell11Pfizer Inc, Groton, CT, USA; 2Tandem Labs, Durham, NC, USA; 3BioCryst Pharmaceuticals Inc, Durham, NC, USA; 4Alta Vetta Pharmaceutical Consulting LLC,
Tse S, Powell KD, MacLennan SJ, Moorman AR, Paterson C, Bell RR   +5 more
doaj  

Dermal exposure and health risk assessment of emamectin benzoate among Thai farmers in Phitsanulok

Journal of Agriculture and Food Research
Emamectin benzoate (EB1) is a widely used pesticide in Thailand for controlling pests in rice and corn production. This study aimed to assess dermal exposure to EB1 among farmers using patch sampling and to evaluate the associated health risks.
Theerayut Baubhom, Brian T. Buckley, Saowanee Norkaew   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Application of Xenogenic Acellular Dermal Matrix for Reconstruction of Cervical Tracheal Defects in a Rabbit Model

B-ENT, 2023
Objective: The aim of this study was to explore the safety of xenogenic acellular dermal matrix for tracheal reconstruction and to explore the process and effectiveness of mucosal repair. Methods: A total of 22 rabbits were divided into the control group
Ping Li, Shisheng Li, Jinkun Li, Xinming Yang   +3 more
doaj   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Validation of dermal patches as a non-invasive tool for monitoring amphibian steroid hormones

Frontiers in Conservation Science
Global amphibian populations are declining, driven by a complex interplay of stressors including habitat destruction, climate change, pollutants, invasive species, and emergent diseases.
Alicia M. Dimovski, Aimee J. Silla, Emily Nimmo, Kerry V. Fanson   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source