Results 71 to 80 of about 281,777 (272)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Travelling-wave similarity solutions for an unsteady shear-stress-driven dry patch in a flowing film [PDF]

, 2013
We investigate unsteady flow of a thin film of Newtonian fluid around a symmetric slender dry patch moving with constant velocity on an inclined planar substrate, the flow being driven by a prescribed constant shear stress at the free surface of the film
Duffy, B.R., Wilson, Stephen, Yatim, Y.M.   +2 more
core   +3 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Bilateral Naevus Of OTA

Indian Journal of Dermatology, 2001
Naevus of Ota is a type of dermal melanocytic naevus characterized by extensive blue patch of dermal melanocytic pigmentation of the sclera and the skin adjacent to the eye. The condition is usually unilateral.
Ahmad Qazi Masood, Hassan Iffat, Quyoom Seema   +2 more
doaj  

Effectiveness of double-layer artificial dermis repair material combined with autologous skin patch in repairing deep skin and soft tissue defects: a retrospective study

Journal of Dermatological Treatment
Objectives With the development of biotechnology, double-layer artificial dermis repair material has been increasingly employed to repair deep skin and soft tissue defects.
Yuhuai Xu, Yan Liu, Peng Cao, Jiaxing Chen, Bingrun Li, Yu Wang, Litao Zhang, Shujing Liu   +7 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Rapid Sampling of Large Quantities of Interstitial Fluid from Human Skin Using Microneedles and a Vacuum-assisted Skin Patch

Bio-Protocol
Interstitial fluid (ISF) is a promising diagnostic sample due to its extensive biomolecular content while being safer and less invasive to collect than blood.
Elizabeth Wilkirson, Xue Jiang, Peter Lillehoj   +2 more
doaj   +1 more source

Human dermal allograft patch cushioning augmentation in large rotator cuff repair [PDF]

Clinics in Shoulder and Elbow
In large posterosuperior rotator cuff tears, retear is more likely due to factors such as poor tendon quality, tendon loss, incomplete footprint coverage, and incomplete repair.
Eugene Baek, Hyun Gon Kim, Jong Hyun Lee, Seung Jin Yoo, Je Hyeong Jo, Su Cheol Kim, Jae Chul Yoo   +6 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The effect of virgin coconut oil loaded solid lipid particles (VCO-SLPs) on skin hydration and skin elasticity [PDF]

, 2013
Virgin Coconut Oil is usually extracted from well matured and fresh coconut through specialized processes without damaging its natural nutrition. In this work, formulation, characterization and efficacy of VCO-SLPs have been studied.
Sarmidi, Mohamad Roji, Mohamed Noor, Norhayati, Abd. Aziz, Azila, Aziz, Ramlan   +3 more
core   +1 more source