Results 161 to 170 of about 74,225 (244)
Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis
Allergy, EarlyView.This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz +7 morewiley +1 more sourceDendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy
Allergy, EarlyView.Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...Anuj Tharakan, Xufeng Qu, Carmen Camarena, Araba Abaidoo‐Myles, Parth Naik, Jeremy Allegood, Ankit Kumar, Mihir Pokhriyal, Joseph C. Lownik, Matthew P. Zellner, Grayson W. Way, Jinze Liu, Lauren Ashley Cowart, Stephanie C. Eisenbarth, Joseph W. Landry, Daniel H. Conrad, Rebecca K. Martin +16 morewiley +1 more sourceClassification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @IT.2020 Project
Allergy, EarlyView.Daily prospective symptom reports from participants in this multicentre observational study were compared to retrospective (last 12 months) reports based on ARIA clinical questionnaire. Retrospective reports substantially underestimated, and to a lesser extent overestimated, symptom frequency compared to e‐Diary prospective reports. Since retrospective Stephanie Dramburg, Camilo J. Hernandez Toro, Ulrike Grittner, Ekaterina Potapova, Alessandro Travaglini, Salvatore Tripodi, Stefania Arasi, Simone Pelosi, Francesco Monnati, Aydan Acar Şahin, Xenophon Aggelidis, Andrea Barbalace, Anne Bourgoin, Blerina Bregu, Maria Antonia Brighetti, Elsa Caeiro, Sule Caglayan Sozmen, Lucia Caminiti, Denis Charpin, Mariana Couto, Luís Delgado, Andrea Di Rienzo Businco, Claire Dimier, Maria V. Dimou, João A. Fonseca, Ozlem Goksel, Dolores Hernandez, Tara Maria Hoffmann, Dah Tay Jang, Fusun Kalpaklioglu, Blerta Lame, Ruth Llusar, Michael P. Makris, Angel Mazon, Eris Mesonjesi, Antonio Nieto, Ayse Bilge Öztürk, Laurie Pahus, Giovanni Battista Pajno, Ilenia Panasiti, Nikolaos G. Papadopoulos, Elisabetta Pellegrini, Ana Margarida Pereira, Mariana Pereira, Munevver Pinar, Alfred Priftanji, Fotis Psarros, Cansin Sackesen, Ifigenia Sfika, Javier Suarez, Michel Thibaudon, Ulas Uguz, Valentine Verdier, Valeria Villella, Paraskevi Xepapadaki, Duygu Yazici, Paolo M. Matricardi +56 morewiley +1 more sourceSkin Abnormalities at Checkpoint Inhibitor Therapy Initiation Are Associated With Skin Rash Development in Oncology Patients
Allergy, EarlyView.Skin tape strip lipidomic analysis revealed preexisting skin barrier lipid abnormalities at day 0 that were further exacerbated after 6 weeks of CPI treatment. Significant changes in skin (but not plasma) proinflammatory cytokines were identified in future ircAE patients after 6 weeks of CPI immunotherapy.Taras Lyubchenko, Evgeny Berdyshev, Ryan M. Weight, Olivia Xiao, Neil J. Shah, Alina Markova, Mario E. Lacouture, Jeffrey A. Kern, Elena Goleva, Donald Y. M. Leung +9 morewiley +1 more sourceShotgun Metagenomics Reveals Skin Microbiome Composition and Function in Infant Atopic Disease
Allergy, EarlyView.Deep shotgun metagenomics profiled > 1000 infant skin swabs in the VITALITY cohort. Distinct skin microbiome signatures separated AD alone from AD with allergic co‐occurrence. Early Staphylococcus enrichment preceded later AD with allergic co‐occurrence. FLG mutations and strain‐level analyses revealed host and microbial features linked to AD.Zeyang Shen, Jana K. Eckert, Richard Saffery, Katrina J. Allen, Audrey Walsh, VITALITY team, Kirsten Perrett, Katrina J. Allen, Justin Brown, Natalie Carvalho, Nigel Curtis, Kim Daziel, Shyamali Dharmage, Ronda Greaves, Lyle Gurrin, Li Huang, Jennifer Koplin, Katherine Lee, Georgia Paxton, Rachel Peters, Anne‐Louise Ponsonby, Peter Sayre, Mimi Tang, Peter Vuillermin, Melissa Wake, Angela Young, Deborah Anderson, Christine Axelrad, Anna Bourke, Kirsty Bowes, Tim Brettig, Natasha Burgess, Beatriz Camesella‐Perez, Xueyuan Che, Daniela Ciciulla, Jac Cushnahan, Helen Czech, Thanh Dang, Kathryn Dawes, Jana Eckert, Hannah Elborough, Michael Field, Charlie Fink, Sarah Fowler, Grace Gell, Rebecca Gray, Emi Habgood, Richard Hall, Phoebe Harris, Erin Hill, Kensuke Hoashi, Hannah Ilhan, Narelle Jenkins, Andrew Knox, Clare Morrison, Melanie Neeland, Jenn Ness, Wendy Norton, Sasha Odoi, Mary Panjari, Kayla Parker, Ahelee Rahman, Ashleigh Rak, Maisie Ralphsmith, Natalie Schreurs, Carrie Service, Victoria Soriano, Judith Spotswood, Mark Taranto, Leone Thiele, Kate Wall, Audrey Walsh, Angela Walsh, Anita Wise, Andrew Davidson, Arul Earnest, Lara Ford, Andrew Kemp, Sam Mehr, Tibor Schuster, Dean Tey, Diana Zannino, Donna Legge, Jason Bell, Joanne Cheah, Kay Hynes, Kee Lim, Emily Porrello, Annette Powell, Pedro Ramos, Anushka Karunanayake, Izabelle Mezzetti, Kayla Parker, Ronita Singh, Harriet Edmund, Bridie Byrne, Tom Keeble, Cuby Martis, Belle Ngien, Penny Glenn, Andrew Kaynes, Clay Deming, Qiong Chen, Karen Laky, Jenny Min Li, Lindsay Chatman, NISC Comparative Sequencing Program, Beatrice B. Barnabas, Sean Black, Gerard G. Bouffard, Shelise Y. Brooks, Juyun Crawford, Holly Marfani, Lyudmila Dekhtyar, Joel Han, Shi‐Ling Ho, Richelle Legaspi, Quino L. Maduro, Catherine A. Masiello, Jennifer C. McDowell, Casandra Montemayor, James C. Mullikin, Morgan Park, Nancy L. Riebow, Karen Schandler, Brian Schmidt, Christina Sison, Sirintorn Stantripop, James W. Thomas, Pamela J. Thomas, Meghana Vemulapalli, Alice C. Young, Heidi H. Kong, Kirsten P. Perrett, Julia A. Segre, Pamela A. Frischmeyer‐Guerrerio +135 morewiley +1 more source
