Results 201 to 210 of about 128,590 (274)

Atopic Dermatitis and Parental Guilt in the United States: Results of a Nationwide Study. [PDF]

open access: yesActa Derm Venereol
Silverberg JI   +6 more
europepmc   +1 more source

Insights into the clinical, platelet and genetic landscape of inherited thrombocytopenia with malignancy risk

open access: yesBritish Journal of Haematology, EarlyView.
Inherited thrombocytopenia (IT) caused by germline variants in RUNX1, ETV6 or ANKRD26 carries a high risk of developing haematological malignancy. This study examined the clinical, platelet and molecular characteristics of 66 patients with these conditions, who carried 24 distinct genetic variants in the corresponding genes.
Ana Marín‐Quílez   +34 more
wiley   +1 more source

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen   +3 more
wiley   +1 more source

JAK–STAT inhibitory effect of IN‐115314, a novel small molecule inhibitor, and pharmacokinetic/pharmacodynamic study in canine

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The JAK–STAT signalling pathway has been extensively spotlighted as a therapeutic target for various diseases. This study assessed the inhibitory effects of a novel small molecule, IN‐115314, on JAK–STAT pathway. Experimental Approach The IC50 values of IN‐115314 for JAK1–pSTAT3 and JAK2–pSTAT5 were determined in canine ...
Jae‐Hun Ahn   +16 more
wiley   +1 more source

Food Allergy in Children in China

open access: yesClinical &Experimental Allergy, EarlyView.
This review highlights significant regional variations in food allergy prevalence across China, with higher rates in economically developed coastal areas. Despite this growing burden, challenges such as limited diagnostic tools, a shortage of allergists and inadequate access to epinephrine autoinjectors hinder effective management of food allergies ...
Agnes Sze‐Yin Leung   +3 more
wiley   +1 more source

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