Results 71 to 80 of about 458,423 (305)

A Compact Optical Sensor to Self‐Assess Skin Health after Sun Exposure

Advanced Sensor Research, EarlyView.
This work presents a portable, low‐cost device capable of detecting changes in the skin associated with excessive sun exposure through reflectance measurements. In vitro validation experiments in skin‐mimicking tissue phantoms showed the device can detect relative pigmentation changes as small as 5%.
Ying Zhi Cheong, Mingjie Yang, Shanmuga Sundar Dhanabalan, Peter Francis Mathew Elango, Sharath Sriram, Blanca del del Rosal, Madhu Bhaskaran   +6 more
wiley   +1 more source

Influence of Immune Cells and Circulating Inflammatory Cytokines on Pathological Scars: A Mendelian Randomization Study

Clinical, Cosmetic and Investigational Dermatology
Yang Xu,1 Weisheng Zhan,2 Juhua Zhao1 1Department of Dermatology, Nanchong Central Hospital, Nanchong, Sichuan Province, People’s Republic of China; 2College of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, People’s ...
Xu Y, Zhan W, Zhao J
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Expert consensus on clinical treatment dilemmas in elderly patients with atopic dermatitis

Pifu-xingbing zhenliaoxue zazhi
Atopic dermatitis (AD) is a common chronic, recurrent, inflammatory skin disease. With the aging of the global population, the prevalence of atopic dermatitis is increasing in the elderly (>60 years old).
Dermatology Branch of Guangdong Elder Health Care Association
doaj   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

Bioinformatics‑Based Analysis Reveals Diagnostic Biomarkers and Immune Landscape in Atopic Dermatitis

Clinical, Cosmetic and Investigational Dermatology
Mingmei Yang,1 Xiaolei Zhang,1 Chao Zhou,2 Yuanyun Du,1 Mengyuan Zhou,1 Wenting Zhang1 1Department of Dermatology, Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou, People’s Republic of China; 2Institute of Biomedical Engineering
Yang M, Zhang X, Zhou C, Du Y, Zhou M, Zhang W   +5 more
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European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen's disease and basal cell carcinomas

Journal of the European Academy of Dermatology and Venereology, 2019
Topical photodynamic therapy (PDT) is a widely approved therapy for actinic keratoses, Bowen's disease (squamous cell carcinoma in situ), superficial and certain thin basal cell carcinomas.
C. Morton, R. Szeimies, N. Basset-Seguin, P. Calzavara-Pinton, Y. Gilaberte, M. Haedersdal, G. Hofbauer, R. Hunger, S. Karrer, S. Piaserico, C. Ulrich, A. Wennberg, Lasse R. Braathen   +12 more
semanticscholar   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Advanced Science, EarlyView.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang, Yiran Fang, Xiatong Huang, Guichuang Ma, Qianqian Mao, Xiansheng Lu, Guangda Rong, Yunfang Yu, Yuanyuan Wang, Zhenhua Huang, Huiying Sun, Jiani Wu, Wenchao Gu, Na Huang, Jianhua Wu, Rui Zhou, Xiaoxiang Rong, Siting Zheng, Shaowei Li, Gaofeng Wang, Ling Wang, Wenjun Qiu, Luyang Jiang, Peng Luo, Yonggang Liu, Jianping Bin, Yulin Liao, Min Shi, Zuqiang Wu, Jiguang Wang, Wangjun Liao, Gang Chen, Dongqiang Zeng   +32 more
wiley   +1 more source

Spesolimab Treatment in GPP: Impact of IL-36RN Mutations and Concomitant Plaque Psoriasis

Clinical, Cosmetic and Investigational Dermatology
Wei Li,1– 3,* Jingyao Liang,2,* Yuwu Luo,2 Shuting Chen,2 Manqi Xia,2 Hui Ye,2 Bin Yang,1,3 Quan Luo2 1Department of Dermatology, First Affiliated Hospital of Jinan University, Guangzhou, 510630, People’s Republic of China; 2Department of
Li W, Liang J, Luo Y, Chen S, Xia M, Ye H, Yang B, Luo Q   +7 more
doaj  

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Mechanistic Insights into Qin Bi Yin for Psoriasis Treatment Using Network Pharmacology, Experimental Validation, and Molecular Docking

Journal of Inflammation Research
Shouxu Zhang,1,2 Yue Du,1,2 Haomin Zhang,1,2 Xingwu Duan,1 Lingling Li1 1Department of Dermatology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People’s Republic of China; 2Graduate School, Beijing University of Chinese ...
Zhang S, Du Y, Zhang H, Duan X, Li L
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