Results 81 to 90 of about 392,833 (299)

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Syringocystadenoma Papilliferum: A Case Series and Literature Review

Clinical, Cosmetic and Investigational Dermatology
Jingjing Jiang,1,* Qian Liao,1,* Jiao Yang,2 Huan Zhang,3 Shiyan Huang,1 Zilan Xian,1 Zhengzhong Zhang4 1Department of Dermatology, Sichuan Integrative Medicine Hospital, Chengdu, Sichuan Province, People’s Republic of China; 2Department ...
Jiang J, Liao Q, Yang J, Zhang H, Huang S, Xian Z, Zhang Z   +6 more
doaj  

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Restorative Challenges: Reconstruction of Large Axillary Defects Following Surgery for Extramammary Paget’s Disease

Clinical, Cosmetic and Investigational Dermatology
Tian Wang, Han Li, Zhaochao Chen, Lan SunDepartment of Dermatology, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhaochao Chen, Department ...
Wang T, Li H, Chen Z, Sun L
doaj  

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Recurrent Subcutaneous Abscess from Co-Infection with Prototheca wickerhamii and Mycobacterium haemophilum: mNGS Misdiagnosis as Leprosy

Infection and Drug Resistance
Li Jiang,1– 3,* Lili Wei,1– 3,* Xiuying Li,1– 3 Dongyan Zheng,1– 3 Cunwei Cao,1– 3 Meng Li2,4 1Department of Dermatology and Venereology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People’s Republic of ...
Jiang L, Wei L, Li X, Zheng D, Cao C, Li M   +5 more
doaj  

Environmental Causes of Dermatitis

, 2016
Federal University of Rio de Janeiro (UFRJ)Federal University of the State of Rio de Janeiro (UNIRIO),Ibero Latin American College of Dermatology (CILAD)General Polyclinic of Rio de Janeiro Dermatology ServiceBrazilian Dermatology SocietyDepartment of ...
Niemeyer-Corbellini, Joao Paulo, Vidal Haddad, Dirk M. Elston, Lupi, Omar, Laila Klotz, Joao Paulo Niemeyer-Corbellini, Elston, Dirk M., Omar Lupi, Montelo, Livia, Klotz, Laila, Haddad, Vidal [UNESP], Tyring, Stephen K., Livia Montelo, Stephen K. Tyring   +13 more
core   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Predictors of Successful Secukinumab Dose Tapering in Moderate-to-Severe Psoriasis: A Retrospective Study

Psoriasis: Targets and Therapy
Jiawen Chen,1– 4,* Zhixun Xiao,1– 4,* Xueting Zeng,1– 4,* Niu Xiang,1– 4,* Renwei Luo,1– 4 Rongying Chen,1– 4 Beiqi Lin,1– 4 Hui Ke,1– 4 Ting Gong,5 Chao Ji1– 4 1Department of Dermatology, the First Affiliated Hospital of ...
Chen J, Xiao Z, Zeng X, Xiang N, Luo R, Chen R, Lin B, Ke H, Gong T, Ji C   +9 more
doaj  

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source