Results 61 to 70 of about 250,268 (351)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin. [PDF]

, 2019
Maintenance of a population of IL-17-committed γδ T cells in the dermis is important in promoting tissue immunity. However, the signals facilitating γδ T cell retention within the dermis remain poorly understood.
Cyster, Jason G, Gray, Elizabeth E, Laidlaw, Brian J, Ramírez-Valle, Francisco, Zhang, Yang   +4 more
core   +1 more source

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration [PDF]

, 2008
In the age of stem cell engineering it is critical to understand how stem cell activity is regulated during regeneration. Hairs are mini-organs that undergo cyclic regeneration throughout adult life1, and are an important model for organ regeneration ...
A Durward, AE Oro, C Blanpain, C Lo Celso, Cheng-Ming Chuong, Damon de la Cruz, E Fuchs, E Johnson, EA Sausville, FJ Ebling, H Chase, J Huelsken, J Zhang, Julie Ann Mayer, K Kobielak, K Militzer, KA Moore, KS Stenn, L Ma, M Iguchi, M Maurer, M Plikus, Maksim V. Plikus, N Suzuki, P Wu, Philip K. Maini, R Paus, RJ Morris, Robert Maxson, Ruth E. Baker, S Reddy, VA Botchkarev, VA Botchkarev, WE Lowry, XC He, Y Zheng   +35 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

The Superficial Dermis May Initiate Keloid Formation: Histological Analysis of the Keloid Dermis at Different Depths

Frontiers in Physiology, 2017
Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce.
Hu Jiao, Tiran Zhang, Jincai Fan, Ran Xiao   +3 more
semanticscholar   +1 more source

Evaluation of the hazard from exposure to electron irradiation simulating that in the synchronous orbit [PDF]

, 1972
The electron spectrum predicted for the synchronous orbit was simulated to determine the effects that might occur to astroscientists exposed to such irradiation while on a prolonged space station mission in that region.
Bender, R., Foelsche, T., Lippincott, S. W., Montour, J. L., Wilson, I. J.   +4 more
core   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Elastolisis de la dermis media

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 2019
Una mujer de 27 años de edad consultó por presentar placas lineales, eritematosas, en el abdomen, de siete meses de evolución, que sugirieron el diagnóstico clínico de morfea. La biopsia no mostró lesión con la coloración de HE.
Gerzaín Rodríguez
doaj  

The Dermis as a Delivery Site of Trypanosoma brucei for Tsetse Flies

PLoS Pathogens, 2016
Tsetse flies are the sole vectors of Trypanosoma brucei parasites that cause sleeping sickness. Our knowledge on the early interface between the infective metacyclic forms and the mammalian host skin is currently highly limited.
G. Caljon, Nick Van Reet, C. De Trez, M. Vermeersch, D. Perez-Morga, J. Van Den Abbeele   +5 more
semanticscholar   +1 more source

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source